Unit:
Τομέας ΠαθολογίαςLibrary of the School of Health Sciences
Author:
Verveniotis Alexios
Dissertation committee:
Παπαβασιλείου Αθανάσιος, Kαθηγητής, Iατρική , EΚΠΑ
Τούσουλης Δημήτριος, Καθηγητής, Iατρική , EKΠΑ
Φιλιππάτος Γεράσιμος, Καθηγητής, Ιατρική , ΕΚΠΑ
Βαβουρανάκης Εμμανουήλ, Καθηγητής, Ιατρική , ΕΚΠΑ
Σιάσος Γεράσιμος, Αναπληρωτής Καθηγητής, Ιατρική , ΕΚΠΑ
Αγγέλη Κωνσταντίνα, Αναπληρώτρια Καθηγήτρια, Ιατρική , ΕΚΠΑ
Σταματελόπουλος Κίμων, Επίκουρος Καθηγητής, ΕΚΠΑ
Original Title:
Επίδραση των ωμέγα - 3 λιπαρών οξέων στην λειτουργικότητα των μεγάλων αρτηριών σε υγιείς καπνιστές
Translated title:
Effects of omega-3 fatty acids on arterial wall properties in healthy smokers
Summary:
Background: Smoking is associated with endothelial dysfunction and arterial stiffness. Supplementation of omega-3 PUFAs is associated with better prognosis. Aim of this study was to evaluate the effects of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on smoking-induced impairment of arterial function.
Methods: We studied the effect of a 12 weeks oral treatment with 2gr/day of omega-3 PUFAs in 20 healthy smokers on three occasions (day0:baseline, day28 and day84). The study was carried out on two separate arms (omega-3 fatty acids and placebo), according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm), immediately and 20 min after cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Circulating levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were measured.
Results: Compared with placebo, omega-3 PUFAs treatment resulted in a significant improvement in pSm values of FMD (pb0.05), AIx (pb0.001) and PWV (pb0.01). Although, acute cigarette smoking decreased FMD and caused an increase in AIx and PWV, omega-3 PUFAs treatment blunted the acute smoking-induced impairment of FMD (pb0.001), AIx (pb0.05) and PWV (pb0.05) and significantly decreased levels of TNFα (pb0.05) and IL-6 (p=0.01) and increased levels of PAI-1 (p=0.05).
Conclusions: Omega-3 PUFAs improved endothelial function and the elastic properties of the arterial tree in healthy smokers, with a parallel anti-inflammatory effect.
Main subject category:
Health Sciences
Keywords:
Omega-3 fatty acid, Endothelium, Inflammation, Fibrinolysis, Vascular function, Atherosclerosis
Number of references:
232
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Verveniotis Alexios Phd.pdf
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