The Anti-Mullerian Hormone as an important predictor of ovarian cancer, infertility and prognosis of IVF

Doctoral Dissertation uoadl:2771346 240 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2018-06-15
Year:
2018
Author:
Agrapidis Dimitrios
Dissertation committee:
Δημήτριος Λουτράδης, Καθηγητής, Ιατρική, ΕΚΠΑ
Δεληγεώρογλου Ευθύμιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Βλάχος Νικόλαος, Καθηγητής, Ιατρική, ΕΚΠΑ
Πρωτόπαππας Αθανάσιος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Δρακάκης Πέτρος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Στεφανίδης Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Μιχαλά Σταυρούλα, Επίκουρος Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Η προγνωστική αξία της ΑΜΗ (anti-Mullerian Hormone) σε ασθενείς που εντάσσονται σε πρόγραμμα υποβοηθούμενης αναπαραγωγής, σε καλοήθεις και κακοήθεις παθήσεις του μαστού και των ωοθηκών
Languages:
Greek
Translated title:
The Anti-Mullerian Hormone as an important predictor of ovarian cancer, infertility and prognosis of IVF
Summary:
Objectives: The purpose of this study was to determine the diagnostic value of AMH in relation to FSH, LH, the number of follicles, the quality of eggs and pregnancies of patients before IVF, and the AMH levels in benign and malignant diseases of the breast and ovaries.
Methods: The study population consisted of patients in assisted reproduction, before their inclusion in a program. Sample hormonal determinations were made using the AMH Gen II ELISA and the statistical analysis with the SPSS statistical package, version 17.00 (SPSS Inc, Chicago, IL).
Results: The results showed that AMH (AUC: 0.618; 0.30-0.93, p=0.474) is not statistically significant predictor of breast cancer, while is a reliable predictor of ovarian cancer (AUC: 0.732; 0.56-0.91, p = 0.011). AMH (AUC: 0.614; 0.52-0.71, p = 0,015) showed a statistically significant association with infertility, age (r = -0.261 p = 0,005), the FSH (r = -0.226 p = 0,017), the LH (r = 0.236 p = 0,012), the follicle (r = 0.527 p <0,001) and ova (r = 0.452 p <0,001).
Conclusions: The present study showed that AMH appears as an important predictor of ovarian cancer, infertility, and prognosis of IVF. Instead, it was not a good predictor in breast cancer. As the research sample is small, further research is needed, as with a widely accepted indicator of AMH.
Main subject category:
Health Sciences
Keywords:
Anti-Müllerian hormone (AMH), In vitro fertilization (IVF), Subfertility, Ovarian neoplasms, Breast cancer
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
441
Number of pages:
159
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