Supervisors info:
Γαζούλη Μαρία, Αναπληρώτρια Καθηγήτρια, Ιατρικής, ΕΚΠΑ
Ευσταθόπουλος Ευστάθιος, Καθηγητής, Ιατρικής, ΕΚΠΑ
Κουτσιλιέρης Μιχαήλ, Καθηγητής, Ιατρικής, ΕΚΠΑ
Summary:
In the last few years, great progress has been made in the research of Nanomedicine used for diagnostic and therapeutic purposes. It is about an emerging scientific field that can be applied in medicine, due to the use of Nanotechnology, for both advanced treatment and diagnosis. The synthesis of Nanomedicine, which involves merging research areas such as chemistry, biology, physics, mathematics and engineering, thus bridging the gap between molecular and cellular interactions, has the power to revolutionize current medical practice.
This study focuses on the recent developments in the field of nanopharmaceutical research and aims to demonstrate the important application in the treatment of serious diseases, such as cardiovascular disorders (eg atherosclerosis, restenosis, myocardial infarction, etc.), neurodegenerative diseases (Alzheimer's disease, Parkinson disease, etc.), and above all, the diagnosis and treatment of cancer. In particular, it is going to be discussed the use of specially designed drugs, the synthesis of which is based on Nanotechnology, aiming at the early detection, molecular imaging and therapy of the aformentioned diseases.
In order to compose this thesis, there has been used registered bibliographic data, which has been assessed, properly treated, and presented in an integrated and detailed way under a summary format. In particular, it was attempted a thorough analysis of Nanomedicines’ mechanisms of action in treating cancer and other serious diseases, with an indication of the advantages and disadvantages that may show in relation to already existing treatments.
There had also been an analysis of experimental data and extensive reference to the current situation and the expected results from the future use of nanomedicines and other structures based on Nanomedicine Technology.
Keywords:
Nanotechnology, Nanomedicine, Nanoparticles, Nanomedicine, Top down, Bottom up, Nanocarriers