Unit:
ΠΜΣ Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Supervisors info:
Λυρίτης Γεώργιος, Ομοτιμός Καθηγητής, Ιατρική, ΕΚΠΑ
Δοντά Ισμήνη-Νίκη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Τριανταφυλλόπουλος Ιωάννης, Επ. Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Φυματίωση των οστών σε ασθενείς χωρίς πνευμονική συμμετοχή
Translated title:
Bones tuberculosis in patient without pulmonary involvement
Summary:
Tuberculosis (TB), is one of the most ancient disease that influents humans and the most crucial cause of death from a bacterial infectious disease, in the world. The most common and in same time important factor of this disease is Mycobacterium tuberculosis.
One third of world population, who are approximately 1.8 billion people, are affected by this disease. In 2016, WHO’s Global Tuberculosis Report, was reported 6.3 million new cases (all forms of TB, both pulmonary and extrapulmonary) up from 6.1 million in 2015. 10% of extrapulmonary cases are bones and joints TB.
During the end of 1980s and the beginning of 1990s, in industrialized countries, the numbers of reported cases of TB was increased. This problem was related to infection HIV, immigration, social problem (urban poverty, homelessness, drug abuse) and these are high- risk patient.
High index of suspicion is the key to the early diagnosis of TB. The major issue amongst the people with TB, especially with bones and joint TB is that the initiation procedure can often delay due to non- specific symptoms. This means that some patients with tuberculsis may have progressed disease. The etiology of disease can confirm by the aspiration of the abscess or bone biopsy, as the cultures of this samples are usually positive and the histologic findings highly typical.
Decreasing the time to diagnosis and, in particular, the time to treatment initiation, are critical in preventing long term damage of bones and joints and should be treated in collaboration among multiple specialists- orthopedics, neurologists, and infection specialists. Optimal duration of treatment also remains under dispute, while the majority of researchers support a regimen of 9month duration, although 6-12months are also proposed.
Main subject category:
Health Sciences
Keywords:
Tuberculosis, Bones, Joints, Pott’s disease, DOT-program
Number of references:
108
File:
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