Postgraduate Programme Biostatistics & Health Science Data
Library of the School of Health Sciences

2018-06-27

2018

Kanavarou Ioanna

Κλέα Κατσουγιάννη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Βάνα Σύψα, Επίκουρη Καθηγήτρια, Ιατρική, ΕΚΠΑ
Φώτης Σιάννης, Επίκουρος Καθηγητής, Μαθηματικό, ΕΚΠΑ

Βιοαλλεργιογόνα στην ατμόσφαιρα και εξάρσεις άσθματος: συστηματική ανασκόπηση και μετα-ανάλυση

Greek

Bioallergens in atmosphere and asthma exacerbations: systematic review and meta-analysis

The adverse effects of exposure to aeroallergens in the atmosphere on the exacerbations of asthma are investigated in some epidemiological studies. The additional exposure to air pollution is associated with increased acute attacks of asthma. The purpose of this Dissertation was the systematic review and meta-analysis of studies investigating the effects of aeroallergens on asthma exacerbations. The literature search was implemented through the electronic database “Pubmed”. The number of studies identified after the initial reading of 763 titles and 66 abstracts was 8 and of these only 6 had comparable exposures and outcomes. Thus, we performed meta-analysis investigating the effect of concentrations of pollen and fungi on the number of daily exacerbations of asthma. The meta-analysis showed that there is a positive association between the increase in concentrations of pollen and asthma exacerbations, but this reached the nominal level of statistical significance only for pollen from trees, and that there is no association between concentrations of fungi and asthma exacerbations. More specifically, in relation to pollen, an increase of 100 particles/m3 in the concentration of pollen from grasses was associated with 0.4% increase in the daily number of asthma exacerbations (p=0.168) . An increase of 20 particles/m3 in the concentration of pollen from weeds was associated with 0.7% and 0.1% increase in the daily number of asthma exacerbations respectively (p=0.092 and p=0.624 ) . Αn increase of 100 particles/m3 in the concentration of pollen from trees was associated with 2.3% and 2.9% increase respectively in the daily number of asthma exacerbations (p<0.05) . In relation to fungi, no association between concentrations of Ascomycetes, Basidiomycetes, Deuteromycetes and asthma exacerbations was observed. In conclusion, there is a need for more studies investigating the effects of pollen and fungi on asthma exacerbations and use of standardized methodologies to yield comparable results.

Health Sciences

Bioallergens, Asthma exacerbations, Asthma, Pollen, Fungi

No

0

Yes

123

56

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https://pergamos.lib.uoa.gr/uoa/dl/object/2775751