Modelling reaction time distribution in schizophrenia with Ratcliff’s Diffusion Model

Postgraduate Thesis uoadl:2775963 369 Read counter

Unit:
Διακρατικό ΠΜΣ Κλινική Νευροψυχολογία-Νοητικές Νευροεπιστήμες
Library of the School of Health Sciences
Deposit date:
2018-06-28
Year:
2018
Author:
Andreakos Nikolas
Supervisors info:
Νικόλαος Σμυρνής, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Ιωάννης Ζαλώνης, Επικ. Καθηγητής, Ιατρική, ΕΚΠΑ
Σωκράτης Παπαγεωργίου, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Modelling reaction time distribution in schizophrenia with Ratcliff’s Diffusion Model
Languages:
English
Translated title:
Modelling reaction time distribution in schizophrenia with Ratcliff’s Diffusion Model
Summary:
Slowing of processing speed is observed in patients with schizophrenia. The present study aimed to model RT distribution in a simple decision task in schizophrenia patients and their first-degree relatives to identify, which of the modelled processes, that are deviant in these patients, have state dependent and which trait dependent characteristics. Schizophrenia patients, siblings of patients and healthy controls performed a combined two-choice oddball, verbal n-back task and the RT distributions were modelled using the DDM model. RT model parameters were compared among patients, siblings and healthy controls. Use of the Drift Diffusion Model (DDM) showed a decrease in the speed of the basic decision process (diffusion drift rate (v)) in patients and relatives compared to controls. Also, an increase in the mean of the non-decisional processing time (t0) was present only for patients. These results could provide evidence for the heritability of the decrease in the speed of decision processing in schizophrenia that could be shared with other mental disorders such as Attention Deficit Hyperactivity Disorder.
Main subject category:
Health Sciences
Keywords:
Schizophrenia, Difussion Model, Reaction time
Index:
No
Number of index pages:
0
Contains images:
No
Number of references:
28
Number of pages:
19
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