Unit:
ΠΜΣ Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Supervisors info:
Τριανταφυλλόπουλος Ιωάννης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Λυρίτης Γεώργιος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ
Δοντά Ισμήνη-Νίκη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Η εφαρμογή των PRPs στους μύες, τένοντες και συνδέσμους.
Translated title:
Applications of PRPs in muscles, tendons and ligaments.
Summary:
Soft tissue injuries are the main cause of morbidity, disability and medical costs worldwide. They have an increased prevalence both in the general population and even more in professional athletes, leading to an emotional strain and pressure of the patient. Recently, the ever-growing branch of biomedical technology has brought to the forefront the treatment at the cellular level with the use of autologous blood products. In this context, the popular PRP therapy is currently underway. PRPs (platelet-rich plasma) are a high platelet concentrate and as a result, growth factors derived from autologous blood, following centrifugation in specific devices. Essentially, this is a combination of growth factors within a blood clot, serving as a carrier. This clot consists of fibrin, fibronectin and vitronectin, which are cell-adhesion molecules needed for cellular migration as seen in the epithelialization of the wound. The growth factors released by platelets through their degranulation are responsible for the anabolic action of the PRPs. PRPs are now an alternative therapeutic approach to muscle, tendon and ligament injuries. The bibliography is complete from studies of the basic science of growth factors and their effect on the regeneration and healing of soft tissues in animal models. However, it is characterized by significant poverty of well-organized controlled studies in human patients, which take into account all the necessary parameters. There appears to be sufficient scientific data on the efficacy of PRPs in injuries such as 1st and 2nd degree muscle strain and lateral epicondylitis of elbow, while for others such as tendinopathy of the rotator cuff of the shoulder and rupture of ACL, the results of the research so far is ambiguous. The aim of this diploma thesis is to highlight the role of PRPs in the healing process of soft tissue and to evaluate them through bibliographic research. Continuing research can adequately clarify the effect of PRPs, so that in the future there would be the possibility of clinical recommendations for their use in the management of soft tissue lesions.
Main subject category:
Health Sciences
Keywords:
Platelet, Plasma, Muscle, Tendon, Ligament
Number of references:
183
