Unit:
ΠΜΣ Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Ioannidis Dimitrios
Supervisors info:
Ευανθία Κασσή, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ,
Λυρίτης Γεώργιος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ,
Τριανταφυλλόπουλος Ιωάννης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Η θέση του ασκορβικού οξέος στον οστικό μεταβολισμό
Translated title:
Ascorbic acid and bone metabolism
Summary:
Vitamin literally means "substance that maintain life". Vitamins are divided in hydrophilic and lipophilic depending on whether they need fat or water to be absorbed. Ascorbic acid which is a water-soluble vitamin, is a glucose derivative; a carbohydrate with six carbon cylinders. Ascorbic acid has pleiotropic effects on the human body. Its best known action is that on the collagen; deficiency leads to scurvy. Ascorbic acid is found in various fruits and vegetables but mainly in citrus fruits. It is absorbed in the intestinal tube through the SVCT-1 and SVCT-2 sodium dependent channels. The required daily intake is 100-200 mg in adults. Ascorbic acid is crucial for the bone remodelling process. On osteoblasts, It increases Osterix and Hif1a (Hypoxia inducible factor 1a) and many other transcriptional factors (TGFβ, ERα, OPN), whereas in osteoclasts most studies indicate that it can suppress osteoclastogenesis. On chondrocytes, ascorbic acid, induces differentiation and also induces collagenous and non-collagenous proteinosynthesis. In terms of the prevention and treatment of osteoporosis, data from retrospective and clinical trials indicate that high daily doses of ascorbic acid (500-1000mg) have beneficial effects on osteoporosis and could be used supplementary to antiresoptive therapies. Other studies have also shown that it helps on fracture healing and posttraumatic complex regional pain syndrome.
Main subject category:
Health Sciences
Keywords:
Ascorbic acid, Vitamin C, Osteoblast, Osteoclast, Bone metabolism