Modern molecular classification of colorectal cancer

Postgraduate Thesis uoadl:2777503 324 Read counter

Unit:
ΠΜΣ Νεοπλασματική Νόσος στον Άνθρωπο: Σύγχρονη Κλινικοπαθολογοανατομική Προσέγγιση και Έρευνα
Library of the School of Health Sciences
Deposit date:
2018-07-09
Year:
2018
Author:
Chaleplidis Nikolaos
Supervisors info:
Α.Χ.Λάζαρης, Καθηγητής, Ιατρική, ΕΚΠΑ
Ν.Καβαντζάς, Καθηγητής, Ιατρική, ΕΚΠΑ
Ε.Θυμαρά, Επικ. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Σύγχρονη μοριακή ταξινόμηση ορθοκολικού καρκίνου
Languages:
Greek
Translated title:
Modern molecular classification of colorectal cancer
Summary:
Colorectal cancer (CRC) is one of the most frequent human cancers globally, accounting for more than a million new cases annually and thousands of deaths per year. A set of factors, both environmental and genetic, has been incriminated for the appearance of the disease, and a proportion of cases seems to have a familiar basis. Since several years ago and until recently, there are numerous studies that try to analyze the molecular background of this disease and to describe the mechanisms of carcinogenesis in the colon. The results highlight that the disease we call “colorectal cancer” is not a single entity, but it shows different faces and subtypes, with analogous extensions regarding their prognosis and treatment. Nowadays, there are many insights regarding
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the model of colorectal carcinogenesis, and although there are still things which remain to be clarified, this model can become, in conjunction with the frequency of the disease and the ease of access and prevention of the premalignant lesions of the colon, a “roadmap” for understanding the pathogenesis of other forms of human cancer as well.
Main subject category:
Health Sciences
Keywords:
Colorectal Cancer, Molecular Classification, Chromosomal Instability, Microsatellite Instability, Methyliosis
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
82
Number of pages:
80
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