Unit:
ΠΜΣ Μονάδες Εντατικής Θεραπείας και Καρδιολογική ΝοσηλευτικήLibrary of the School of Health Sciences
Supervisors info:
Κωνσταντίνος Τούτουζας, Αναπληρωτής Καθηγητής , Ιατρική, ΕΚΠΑ
Ελένη Κυρίτση, Καθηγήτρια, Νοσηλευτική, Πανεπιστήμιο Δυτικής Αττικής
Δημήτριος Τούσουλης, Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Σύγκριση φλεγμονής καρωτίδων μεταξύ υγειών και ασθενών με γνωστή Στεφανιαία Νόσο μετρούμενη με ακτινομετρία μικροκυμάτων
Translated title:
Comparison of carotid artery inflammation, among healthy and patients with known Coronary heart disease , mesured by microwave radiometry
Summary:
OBJECTIVES: Increased vigilance is required to identify vulnerable atherosclerotic plaque and vulnerable patient in order to improve strategies for the prevention and treatment of atherosclerotic diseases, which are the main cause of death in civilized world. Microwave Radiometry is a method which detects non-invasively and accurately changes of temperature in human tissues and provides the possibility of safe use for the temperature measurement of arterial walls, indicating the level of inflammation.
PURPOSE: The goal of the present study is the detection of carotid artery inflammation, using Microwave Radiometry (MWR), in patients with known coronary heart disease and in healthy population. As well as the correlation between the carotid temperature difference and the presence of Coronary Disease.
METHODS: 326 patients with known Coronary Disease and a group of 145 healthy people were subjected to carotid ultrasound and carotid temperature measurements with MWR. Atherosclerotic plaques were evaluated sonographically regarding their morphology, την ηχογένεια and evenness. Thermal heterogeneity (ΔT) was assigned as maximal temperature along the carotid artery minus minimum.
RESULTS: Mean maximum value of the carotid intima-media thickness (ccIMTmax) was found 0,942 in patients and 0,448 in control group (p<0.001). Carotid plaque in at least one of the two carotids was detected in 86% of patients while in 66% the plaque was detected in both carotid arteries. No carotid plaque formation was observed in the control group in either carotid artery. Mean maximum value of ΔΤ (ΔTmax) was observed as 0,913 in patients and 0,539 in control group (p<0.001). High thermal heterogeneity in at least one carotid artery detected in total of 44.5% patients and 4.5% of control group (p<0.01). More specifically in control group smoker’s present higher levels of ΔΤ than no-smokers while BMI doesn’t seem to correlate with high heterogeneity.
CONCLUSIONS: while in control group there is no correlation among (ΔT) rıght and left carotıd artery ın patıents wıth known Coronary Dısease there is a positive and mediocre to strong correlation. It was observed also that in control group the ΔΤ is statistically significantly associated with smoking, with smokers showing higher ΔT values than non-smokers. Temperature measurements in control group show a normal distribution with a small standard deviation, indicating the value of the method as a biomarker.
Main subject category:
Health Sciences
Keywords:
Microwave radiometry, Thermal eterogenity, Carotid inflammation, Carotid plaque
Number of references:
109
