Supervisors info:
Αικατερίνη Τυλιγάδα, Αναπληρώτρια Καθηγήτρια Ιατρική ΕΚΠΑ Εργαστήριο Φαρμακολογίας
Ουρανία Τσιτσιλώνη, Αναπληρώτρια Καθηγήτρια Ανοσολογίας, Τμήμα Βιολογίας ΕΚΠΑ
Ιορδάνης Μουρούζης, Επίκουρος Καθηγητής Φαρμακολογίας, Ιατρική ΕΚΠΑ
Summary:
The aim of this analytical, retrospective, observational study was to
evaluate a 'Drug Allergy' archive of reported drug hypersensitivity
reactions (DHRs) that were recorded between 2007-2016 in the Allergy
Unit of a tertiary Hospital in Athens, Greece. The main objective was to
identify the association(s) between the characteristics of the patients
with DHRs to NSAIDs or paracetamol, the hypersensitivity reaction and
the culprit drug. Data analysis and processing was performed using IBM
SPSS. The partially normalized subset of the 'Drug Allergy' archive
consisted of data derived from 112 adult patients and was referred to as
'NSAID Hypersensitivity Reaction Record'. Due to the retrospective data
processing, it was not feasible to avoid instruction, design, specialist
and differential/partial verification bias, as well as the Hawthorne effect.
Among the 18 culprit drugs, acetylsalicylic acid, mefenamic acid,
diclofenac and paracetamol were the most commonly reported cause of
the DHRs, the majority of which were reported by female patients.
DHRs manifestations included mainly cutaneous signs and anaphylactic
reactions. In most cases, the symptoms occurred on the first day of
treatment, within 1 hour of drug intake, and lasted up to 24 hours.
Mostly immediate DHRs were reported for paracetamol, mephenamic
acid, acetylsalicylic acid, ibuprofen and etoricoxib, while DHRs to
oxicams were predominantly delayed hypersensitivity reactions. The
outcome of this work provides the basis for the design of more
comprehensive and extensive studies aimed at the investigation of the
mechanisms governing DHRs to NSAIDs and paracetamol.
Keywords:
drug allergy, NSAIDs, Non steroidal anti inflammatory drugs, clinical data, hypersensitivity reactions