Κατεύθυνση Στοματολογία (Κλινικές Ειδικεύσεις)Βιβλιοθήκη Οδοντιατρικής
Κωνσταντίνος Τόσιος, Επίκουρος Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ
Αλεξάνδρα Σκλαβούνου-Ανδρικοπούλου, Καθηγήτρια, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ
Ευαγγελία Πιπέρη, Επίκουρη Καθηγήτρια, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ
Ανοσοϊστοχημική διερεύνηση της έκφρασης των μορίων EDA1 και EDAR σε οδοντογενείς κερατινοκύστεις
Immunohistochemical study of the expression of EDA1 and EDAR proteins in odontogenic keratocysts
Ιntroduction: Odontogenic keratocyst (ΟΚ) is an odontogenic developmental cyst, speculated to derive from remnants of the dental lamina. Its pathogenesis has not been resolved, although the Sonic Hedgehog signaling pathway (SHH) seems to play a fundamental role. Ectodysplasin (EDA), a member of tumor necrosis factor superfamily, participates in tooth development and interacts with signaling pathways, including SHH.
Objectives: To investigate the immunohistochemical expression of EDA and EDA receptor (EDAR) in OKs.
Material and Methods: EDA expression was assessed by a routine immunohistochemical method in 30 non syndromic and non recurrent OKs from 30 patients, and 10 dentigerous cysts (DCs) as controls, whereas EDAR was investigated in 20 OKs and 5 DCs. All specimens were retrieved from the archives of the Oral Pathology Laboratory of the Department of Oral Medicine and Oral Pathology, National and Kapodistrian University of Athens, Greece.
Results: EDA expression was either cytoplasmic or both cytoplasmic and nuclear whereas EDAR expression was strictly cytoplasmic. EDA was expressed in all OKs and dentigerous cysts, whereas EDAR in 3/21 OKs but in 4/5 DCs. A statistical significant difference was detected in EDAR expression between OKs and DCs (p<0.05).
Conclusions: EDA does not seem to participate in the pathogenesis of OK, but lack of EDAR expression is supportive of its purported derivation from the dental lamina epithelium.
Main subject category:
Odontogenic keratocyst, Odontogenic cysts, Ectodysplasin
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