GSTM1 polymorphism in endometriosis in greek women

Postgraduate Thesis uoadl:2778753 321 Read counter

ΠΜΣ Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences
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Liokari Maria-Emmanouela
Supervisors info:
Λουτράδης Δ., Καθηγητής, Ιατρική, ΕΚΠΑ
Δρακάκης Π., Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Ντόμαλη Κ., Επίκουρη Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Ο πολυμορφισμός GSTM1 στην ενδομητρίωση στον ελληνικό γυναικείο πληθυσμό
Translated title:
GSTM1 polymorphism in endometriosis in greek women
GSTM1 is a member of the GST family proteins which catalyze the conjugation of glutathione to potentially genotoxic compounds. GSTM1 is involved in the detoxification of polycyclic aromatic hydrocarbons and other mutagens. It is also shown that the polymorphism in GSTM1 gene is caused by a gene deletion which results in the absence of enzyme activity in individuals with the homozygous null genotype. Previous studies suggested that the null genotype of GSTM1 can lead to high endometriosis risk, especially in European and Asian populations. Thus, it might promote the occurrence and development of endometriosis. We studied endometriotic tissue from 29 Greek women with infertility and histologically confirmed endometriosis, as well as blood samples from 49 controls, who have had at least one successful pregnancy and no miscarriages. According to statistical analysis, 34,5% of endometriosis cases have the homozygous null genotype in contrast with 18,4% of controls (95% CI, p = 0,171). The absence of allele tends to have a statistically significant association with the age of initiation of symptoms (p = 0.044). Additionally when blood sample and endometriotic tissue from the same woman were studied for the presence of the allele, a different genotype was found in 10 out of 29 women. The above findings may be relevant to a cellular and molecular explanation of the causes of endometriosis. Concerning the mechanisms underlying endometriosis a possible impact of environmental factors may be evaluated. The establishment of a genetic profile may improve the prediction of the reappearance of endometriotic lesions. An association of the polymorphism with clinical characteristics may help clinicians in consulting and planning treatment in patients with endometriosis.
Main subject category:
Health Sciences
GSTM1, GSTs, Endometriosis
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