Unit:
Τομέας Υγείας - Μητέρας - ΠαιδιούLibrary of the School of Health Sciences
Dissertation committee:
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική, ΕΚΠΑ
Γεώργιος Χρούσος, Καθηγητής,Ιατρική,ΕΚΠΑ
Ιωάννης Φατούρος, Αναπληρωτής Καθηγητής, ΤΕΦΑΑ, Παν. Θεσσαλίας
Χριστίνα Κανακά-Gountenbein, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ευαγγελία Χαρμανδάρη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ειρήνη Λαμπρινουδάκη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Γρηγόριος Μπογδάνης, Επίκουρος Καθηγητής, ΤΕΦΑΑ, ΕΚΠΑ
Original Title:
Μελέτη ενδοκρινολογικών και λιποκυτοκινικών παραγόντων σε προεφηβικά παιδιά σε σχέση με τη σωματική άσκηση
Translated title:
Endocrimological agents and lipocytokines in prepubertal children in relation with physical exercise
Summary:
Purpose: Presumed interrelationships among deleterious aspects of adipose tissue metabolism, inflammation, and cellular oxidative stress could be influenced by pubertal hormonal changes. They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator
Methods :Cross-sectional study. Seventy-six healthy pre- (mean ± SD, 10.6 ± 0.2 years old, 28 normal-weight, and 11 obese) and early-(11.4 ± 0.2 years old, 25 normal-weight, and 12 obese) pubertal boys, were blood-sampled before and after a bout of exercise at 70% VO2 max. Leptin, adiponectin, markers of inflammation (high-sensitivity C-reactive protein, high sensitivity IL-6), pro- (thiobarbitouric acid reactive substances, protein carbonyls) and anti- (glutathione, oxidized glutathione, glutathione peroxidase, catalase, total antioxidant capacity) oxidation were measured.
Results: Baseline and post-exercise adiponectin was greater and leptin and high-sensitivity C-reactive protein were lower in normal-weight than in obese pre- and early pubertal boys, while high sensitivity IL-6 was greater in obese than in normal-weight pre-pubertal boys. In pre-pubertal obese boys: at baseline, high-sensitivity C-reactive protein correlated negatively with catalase; high sensitivity IL-6 correlated positively with protein carbonyls; Δ (difference during exercise) adiponectin correlated positively with Δcatalase. In all boys: at baseline, high sensitivity IL-6 correlated positively with leptin and was the best negative and the second best positive predictor for post-exercise glutathione/oxidized glutathione and protein carbonyls, respectively; leptin was the best negative predictor for postexercise glutathione; waist to height ratio was the best positive predictor for post-exercise thiobarbitouric acid reactive substances; body mass index z-score and adiponectin were, respectively, the best positive predictor for post-exercise protein carbonyls and catalase. FSH(Folicle Stimulation Hormone), LH(Luteinizing Hormone) baseline concentrations were greater in early pubertal boys. LH became lower after exercise in early pubertal boys. Testosterone increased after exercise in early pubertal obese boys. Testosterone baseline concentatios was the best positive predictor for post exercise antioxidation markers. Conclusions In all subjects, leptin and adiponectin predict negatively and positively anti-oxidation, respectively, while high sensitivity IL-6 predicts positively and negatively pro and anti-oxidation, respectively. High-sensitivity C-reactive protein is increased and negatively associated with antioxidation in pre-pubertal obese boys, suggesting that childhood obesity is associated with aseptic inflammation and oxidative stress and anti-oxidation improves in puberty.
Main subject category:
Health Sciences
Keywords:
Puberty, Lipocytokines, Exercise, Endocrinology, FSH, LH
Number of references:
162
