Unit:
ΠΜΣ Νεοπλασματική Νόσος στον Άνθρωπο: Σύγχρονη Κλινικοπαθολογοανατομική Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Supervisors info:
Κορκολοπούλου Πηνελόπη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Παπαδαυίδ Ευαγγελία, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Κουλουλίας Βασίλειος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Θεραπεία Τ δερματικών λεμφωμάτων, με εξωτερική σωματιδιακή (ηλεκτρόνια) ακτινοθεραπεία TSEB (Total Skin Electron Beam)
Translated title:
Treatment T cutaneous lymphomas with TSEB (Total Skin Electron Beam).
Summary:
Primary skin T-lymphomas are a heterogeneous group of neoplastic T cells that appear on the skin without any evidence of extrinsic disease at the time of diagnosis.
Treatments for primary cutaneous T-lymphomas vary according to the stage of the disease.
Due to the fact that almost half of all skin lymphomas are related to Mycosis Fungoides (MF), in the last few years various therapies for treating stage symptoms are proposed. Total skin electron beam radiation therapy,TSEB, is a treatment method that offers complete response rates of 40-90% with most (50%) of patients experiencing limited disease and symptoms like plaques and about 25% of them have a generalized skin plaque disease, both remaining free of disease for many years or even decades.
According to many, various studies, low-dose TSEB regimens are well tolerated and achieve short-term relief, while they are used in patients with disease progression, who have not responded to other therapies. In some cases, it can also be used as a first-line treatment, especially in patients with erythroderma who suffer from Mycosis Fungoides, but without peripheral blood involvement.
Main subject category:
Health Sciences
Keywords:
Mycosis fungoides, Sezary syndrome, TSEB, T cutaneous lymphomas, Electrons
Number of references:
168
