Unit:
Κατεύθυνση Σακχαρώδης Διαβήτης και ΠαχυσαρκίαLibrary of the School of Health Sciences
Author:
Avgouleas Georgios
Supervisors info:
Τεντολούρης Νικόλαος, Καθηγητής, Ιατρική, ΕΚΠΑ
Μακρυλάκης Κωνσταντίνος, Αναπληρωτής Καθηγηγητής, Ιατρική, ΕΚΠΑ
Κόκκινος Αλέξανδρος, Αναπληρωτής Καθηγηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Ινσουλινοαντίσταση και σακχαρώδης διαβήτης επαγόμενα από το ελικοβακτηρίδιο του πυλωρού: βιβλιογραφική ανασκόπηση
Translated title:
Insulin resistance and diabetes mellitus induced by helicobacter pylori: literature review
Summary:
Introduction: Diabetes mellitus (DM) has risen dramatically over the last decades, mainly due to the obesity’s pandemia, while Helicocacter Pylori (H.P.) infection is also very common with recent data showing that it accounts for about 50% of the world's population. Many studies of the past have shown a close relationship between these entities, but the causal relationship has not yet been established.
Aim: The aim of this assay is to review the most recent literature and assess the possible correlation between H.P. infection and glucose homeostasis, as well as the association with DM and Metabolic Syndrome (MS).
Material - Methods: The online MEDLINE / PubMed platform was used to search for literature from January 2016 to today. The articles that were selected at the end for full reading and study were 33 and of these, 25 were used to write the paper. The exclusion criteria were articles not relevant to our topic, simple bibliographic reviews, letters to the editor as and those written in the Russian and Italian language.
Results - Conclusions: Most studies (11 out of 17) showed a correlation between H.P. and disorders in glucose homeostasis, while the eradication of the bacterium produced positive results in half of the studies (2 out of 4). Whether the H.P. infection is associated with insulin resistance, metabolic syndrome and diabetes remains a field of intense debate and the results of the studies are conflicting with each other. In the future, other studies may better elucidate these findings, focusing mainly on showing the sequence of the possible association between H.P. and DM. Finally, works with a larger, more representative sample and more targeted inclusion and exclusion criteria will clarify the involvement of the H.P. infection on the incidence of insulin resistance and DM.
Main subject category:
Health Sciences
Keywords:
Diabetes mellitus, Insulin resistance, Metabolic syndrome, Glucose homeostasis, Helicobacter pylori
