Hypovitaminosis D in healthy pregnant women and their newborns in Greece

Doctoral Dissertation uoadl:2812508 111 Read counter

Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
Sideri Vasiliki
Dissertation committee:
Παπαευαγγέλου Βασιλική, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Παπαδημητρίου Αναστάσιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Πρίφτης Κωνσταντίνος, Αν. Καθηγητής, Ιατρική, ΕΚΠΑ
Ντινόπουλος Αργύριος, Αν. Καθηγητής, Ιατρική, ΕΚΠΑ
Χρέλιας Χαράλαμπος, Αν. Καθηγητής, Ιατρική, ΕΚΠΑ
Αττιλάκος Αχιλλέας, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Παναγόπουλος Περικλής, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Μελέτη επιπέδων βιταμίνης D στην έγκυο και οι επιπτώσεις στο νεογνό
Translated title:
Hypovitaminosis D in healthy pregnant women and their newborns in Greece
Despite vitamin D was discovered a hundred years ago, it has emerged as one of the most controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism and bone health is indisputable, but its role in immune function and long-term health is also being discussed. A series of biological activities involving cell proliferation, differentiation and apoptosis correlate with vitamin D, actions that are equally important for fetal growth and development. Vitamino D deficiency has been increasing over the past 3 decades, with literature focusing on high-risk groups such as pregnant women and newborns
AIM OF THE STUDY: To evaluate the current vitamin D status in healthy pregnant women and their newborns living in Greece and assess possible associations between 25-hydroxyvitamin D [25(OH)D] and anthropometric features of their fetuses and newborns.
MATERIALS & METHODS: 81 healthy women were monitored during pregnancy. Biochemical markers related to bone metabolism, such as 25(OH)D and PTH levels were measured in serum samples of mother-newborn pairs at 1st trimester of pregnancy and at delivery in mothers, in cord blood and at the 3rd day of life of newborns.
RESULTS: Maternal 25(OH)D levels at 1st trimester of pregnancy (22.6±9.2ng/ml) were significantly higher than those at delivery (19.2±9.2ng/ml) (p<0.001). Furthermore, umbilical 25(OH)D levels (21.3±9.3ng/ml) were higher than maternal at delivery (p=0.005) and neonatal levels (19.4±10.4 ng/ml) (p=0.021). Only 57,3% of the mothers at first trimester and 44.1% at delivery as well as 55.8% of the fetuses and 38.4% of the neonates had adequate vitamin D levels (25(OH)D <20ng/ml). A significant positive correlation was found between fetal femur length at 22nd week of gestation and maternal 25(ΟΗ)D at 1st trimester of pregnancy (r=0.36, p=0.048) while body length was significantly higher in newborns whose mothers had sufficient 25(OH)D levels (51.5±2.1ng/ml) compared with those whose mothers had insufficient or deficient 25(OH)D levels at delivery (50.6±2.0 ng/ml) (p=0.047).
CONCLUSION: The study confirms inadequate levels of vitamin D in pregnant women in Greece associated with inadequate vitamin D levels of their fetuses and newborns. Also, the reduced maternal levels of 25 (OH) D are correlated with decreased fetal femur length, at 22nd weeks of gestation, and reduced neonatal body length.
Main subject category:
Health Sciences
Vitamin D deficiency, Vitamin D insufficiency, Pregnancy, Fetus, Newborn
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