Transdermal injection of ozone gas for the treatment of disc herniations

Postgraduate Thesis uoadl:2812705 363 Read counter

Unit:
ΠΜΣ Επεμβατική Ακτινολογία
Library of the School of Health Sciences
Deposit date:
2018-10-22
Year:
2018
Author:
Douka Maria
Supervisors info:
Κελέκης Αλέξιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Φιλιππιάδης Δημήτριος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κελέκης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διαδερμική έγχυση όζοντος για την αντιμετώπιση κήλης μεσοσπονδυλίου δίσκου
Languages:
Greek
Translated title:
Transdermal injection of ozone gas for the treatment of disc herniations
Summary:
Disc herniation is the most common cause for spinal surgery, and the search of a less traumatic treatment is continuous. The mechanical and biochemical inflammatory changes in the area of the herniated disc have led to the injection of ozone, since ozone gas has well known anti-inflammatory and analgesic properties, while at the same time, causes an important volume loss when injected intradiscally.
The aim of this study is to determine the effect of the intradiscal and intraforaminal ozone injection on pain score and satisfaction, in carefully selected patients. The mean score of back and leg pain as well as the functional improvement, assessed through the EuroQol, VAS and RMDQ Questionnaires, were assessed prior to the injection (baseline) and 1 week, one, three, six, twelve, eighteen and twenty-four months after the injection. Twelve patients fulfilled the inclusion criteria and eleven participated in the study, with a mean age of 40.5 years. The mean score (±Standard deviation) of limb pain in the NRS scale was 8 (±1,3) prior to the injection, while that of back pain was 3.9 (±3.5). The limb pain score reduced at 3.5 (± 2.4) one week after the injection, while the reduction was constant, reaching at 1 (±2) two years post- treatment. The back pain score though, did not show statistically significant change during the follow-up period.
Apart from the quantitative measurements, an improvement was recorded in all indexes of the post- treatment functionality of the patients. The mean score in the EQ-5D-5L questionnaire was reduced, from 3.28 (±1.03) at the baseline accessment, reaching at 1.55 (±0.93) 18 months after the treatment. The subjective feeling of health status in every patient was accessed through the hundreadth grade Visual Analogue Scale and the mean score was 55.42 (±20.72) at baseline. We reported a progressive improvement up to 87.5 (±18.93) 18 months after the injection. Finally the mean score in the RMDQ questionnaire was progressively improved, from 18.17 (±3.2) prior to the injection, to 7 (±10.4) 18 months after the treatment. No major complications were reported, after the injection or in the follow-up period.
Consequently, the intradiscal and transforaminal ozone injection is a minimally invasive and relatively cheap procedure, that can offer both short and long-term relief of limb pain, as confirmed from this study’s results, while at the same time can improve the total functional profile of the patient, as shown in the improved scores from the ED-5D and Roland-Morris questionnaires.
Main subject category:
Health Sciences
Keywords:
Ozone gas, Intervertebral disc, Herniation, Minimally invasine treatment
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
93
Number of pages:
102
File:
File access is restricted only to the intranet of UoA.

Douka Maria Msc.pdf
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