Comparison of oxytocin's secretion levels in culture medium retrieved from good and poor quality human embryos

Postgraduate Thesis uoadl:2814972 314 Read counter

ΠΜΣ Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences
Deposit date:
Triantafyllou Eleni
Supervisors info:
Λουτράδης Δημήτριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δρακάκης Πέτρος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ντόμαλη Αικατερίνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σύγκριση των επιπέδων έκκρισης ωoκυτοκίνης στο καλλιεργητικό υγρό ανθρώπινων εμβρύων καλής και κακής ποιότητας
Translated title:
Comparison of oxytocin's secretion levels in culture medium retrieved from good and poor quality human embryos
With the growing desire for infertile couples to reproduce, Assisted Reproductive Technology (ART) provides a means to overcome this challenge. Several techniques exist depending on the extent of the infertility. There has been birth of more than 4 million babies worldwide using ART. However, there are very low rates of successful implantation and pregnancy per transferred embryo in in vitro fertilization.
In this assay, we present that Proteomics has the potential to aid in selection of the best embryo. More specifically, we studied the possibility of linking the presence of the hormone Oxytocin found in the embryo culture media with their quality and thus the establishment of a healthy pregnancy. Consequently, the conclusion reached is that proteomic biomarkers could be a key to establishing a non-invasive, reliable, reproducible, and specific means of assessing endometrial receptivity, embryonic viability, aneuploidy, and fertilizing potential of the sperm. These biomarkers include a variety of both structural and functional proteins. The application of these potential biomarkers in the future will help in enhancing the ART outcomes by offering a personalized treatment for patients based upon their individualized signature proteomics profiles.
Main subject category:
Health Sciences
Oxytocin, Proteomics, Biomarker, Assisted reproduction, Embryo evaluation, Culture media, Non-invasive method
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