Synthesis of double responsive cross-linked hybrid block terpolymers based on polyethyleneoxide, polycysteine and polyhistidine

Postgraduate Thesis uoadl:2815682 76 Read counter

Unit:
Κατεύθυνση Επιστήμη Πολυμερών και Εφαρμογές της
Library of the School of Science
Deposit date:
2018-11-01
Year:
2018
Author:
Mathianaki Aikaterini
Supervisors info:
Ερμόλαος Ιατρού, Καθηγητής, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Original Title:
Σύνθεση διπλά αποκρινόμενων δικτυωμένων υβριδικών τρισυσταδικών συμπολυμερών πολυαιθυλενοξειδίου, πολυκυστεΐνης και πολυϊστιδίνης
Languages:
Greek
Translated title:
Synthesis of double responsive cross-linked hybrid block terpolymers based on polyethyleneoxide, polycysteine and polyhistidine
Summary:
In this work, a series of novel amphiphilic hybrid block terpolymers based on polyethyleneoxide (PEO), polyhistidine (PHis) and polycysteine (PCys) have been synthesized. These terpolymers possess the ability to respond to external stimuli and consist of different molar ratio of PCys to the whole polypeptide part. In addition, a PHis homopolymer was synthesized using a C-terminus protected Cysteine as the macroinitiator in order to bond with different macromolecules via “click” chemistry. The synthetic route for the hybrid terpolymers and the homopolymer was conducted via Ring Opening Polymerization of the corresponding protected N-Caboxy Anhydrides and in the case of the terpolymers mPEO114¬-NH2 was used as the macroinitiator. High Vacuum Techniques were used both for the purification of the solvents and the polymerizations avoiding undesirable sidechain reactions. The desirable polymers were characterized by Size Exclusion Chromatography (SEC/GPC), Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FT-IR) and Dynamic Light Scattering (DLS). By studying the effect of different cross-linking percentages as well as the relationship between the hydrophilic and hydrophobic segments, it is possible to find the optimum polymeric system and draw useful conclusions about these potential drug nanocarriers.
Main subject category:
Science
Keywords:
Ring Opening Polymerization, N-Carboxy Anhydrides, polypeptides, drug delivery, responsiveness
Index:
Yes
Number of index pages:
8
Contains images:
Yes
Number of references:
72
Number of pages:
171

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