Helicobacter pylori: Modern views

Postgraduate Thesis uoadl:2819417 533 Read counter

Unit:
Κατεύθυνση Εργαστηριακή / Βασική Έρευνα
Library of the School of Health Sciences
Deposit date:
2018-11-14
Year:
2018
Author:
Halioti Asimenia
Supervisors info:
Γεώργιος Βαϊόπουλος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μιχαήλ Κουτσιλιέρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταύρος Σουγιουλτζής, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ελικοβακτηρίδιο του πυλωρού: Σύγχρονες απόψεις
Languages:
Greek
Translated title:
Helicobacter pylori: Modern views
Summary:
Helicobacter pylori (H. pylori) is a gram negative, spiral bacterium that colonizes the stomach of approximately 50% of the world population (incidence is higher in the developing countries). The mode of transmission is not totally clear. Gastric fluids or the fecal-oral route are considered the most probable ways of transmission among humans, who constitute the major reservoir of Helicobacter in the environment.
For the diagnosis of H. pylori infection invasive methods are used, that require upper gastrointestinal tract endoscopy, and non-invasive methods, with urea breath test being the most popular.
H. pylori has been implicated in the etiopathogenesis of several upper gastrointestinal tract diseases, such as peptic ulcer disease, gastric adenocarcinoma and the malignant transformation of the lymphoid tissue of gastric mucosa (MALT lymphoma). Moreover, H. pylori has been associated with other diseases, such as iron-deficiency anemia and Behcet-Adamantiades syndrome, and other clinical entities, like hepatic encephalopathy and preeclampsia.
However, up to 85% of H. pylori infected individuals never develop a related disorder. Several independent factors intervene to determine the final clinical outcome of the infection: genetics, the environment and H. pylori-related factors.
H. pylori eradication is of crucial significance for the treatment of peptic ulcer disease as well as for the management of MALT lymphoma of low malignant potential. Antimicrobial regimens and gastric acid secretion inhibitors are used.
The aim of this current project is to bring out the association between H. pylori infection and gastrointestinal and other extra-intestinal diseases through review of the literature. The epidemiology of H. pylori infection, the virulence factors of the bacterium against the host, as well as the clinical manifestations, etiopathogenesis and management of the associated diseases will be reviewed.
Main subject category:
Health Sciences
Keywords:
Helicobacter pylori, Peptic ulcer, Extra-intestinal diseases, ITP
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
34
Number of pages:
33
CHALIOTI ASHMENIA MASTER.pdf (518 KB) Open in new window