Unit:
Τομέας Υγείας - Μητέρας - ΠαιδιούLibrary of the School of Health Sciences
Author:
Papavagelis Christos
Dissertation committee:
Δεληγεώρογλου Ευθύμιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Λαμπρινουδάκη Ειρήνη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Σταματελόπουλος Κίμωνας, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Γιαννακούλια Μαρία, Αναπληρώτρια Καθηγήτρια, Διατροφή-Διαιτολογία, Χαροκόπειο
Πανούλης Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Ευθυμιάδης Μακάριος, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Καπαρός Γεώργιος, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Αξιολόγηση θρέψης σε υγιείς μετεμμηνοπαυσιακές ελληνίδες. Μελέτη της παρέμβασης με μοντέλο μεσογειακού τύπου τρόπου ζωής σε δομικούς και λειτουργικούς δείκτες υπο - ομάδας παχυσάρκων γυναικών
Translated title:
Assessment of nutrition of metamenopausal greek women. A study of a mediterranean way of eating and its association with functional and stuctural arterial indices in a sub group of obese women
Summary:
Introduction: Menopause set women at high risk of developing chronic diseases such as obesity and certain cardiovascular diseases. However, there is lack of studies that have been conducted in a population of postmenopausal women, in order to assess the effect of diet on structural and functional vascular function indices.
Aim: The main aim of this dissertation was to evaluate eating habits in a group of healthy postmenopausal women. At the same time, investigation of the existing relationship between the Mediterranean lifestyle and outcomes of structural and functional arterial indices in a subgroup of postmenopausal women constituted further study objective.
Methods: Study sample was consisted of 638 postmenopausal women recruited from Menopause Clinic of Aretaieio Hospital of Athens. Eligible were women, who had FSH >25 mIU/mL and estradiol <50 pg/mL, after 12 consecutive months without menses. Basic demographic characteristics, medical and menstrual history were recorded from all study participants. Physical activity was assessed by International Physical Activity Questionnaire, dietary intake was assessed by a validated semi-quantitative food frequency and adherence to Mediterranean diet was evaluated through Mediterranean Dietary Score. Finally, anthropometric, biochemical and hormone characteristics were assessed and a standardized physical examination was conducted for each participant.
Results: Mean age of participants was 57.7±7.6 years and BMI was 27.9 ± 5.0 kg/m2. According to MedDietScore, mean adherence to Mediterranean diet was 36.1 ±4.7. Mediterranean diet was negatively associated with BMI and waist circumference in study sample, after controlling for potential confounders. Particularly, high and medium adherence to Meditteranean diet were statistically significant related to lower obesity indices, greater physical activity level and higher education level, compared to menopausal women with low adherence to this dietary pattern. When Principal Component Analysis was applied in a sub-sample of 481 women, 8 dietary patterns were extracted. A pattern characterized by high consumption of dietary fibers and complex carbohydrates was negatively associated with BMI and waist circumference, after controlling for potential confounders. Also, an unhealthy pattern was positively associated with BMI and waist circumference, after controlling for potential confounders. Regarding arterial stiffness, coffee/tea consumption was found to be strongly inversely associated with PWV (r=-0.233, p<0.001) in postmenopausal women. Moreover, dietary intake of refined starches was positively related to IMT of ccca (r=0.116, p=0.04). Specifically, multivariate linear regression showed that consumption of nuts and coffee/tea were negatively associated with CCIMT (b-coefficient=-0.018, p=0.05) and PWV (b-coefficient=-0.327, p=0.002), respectively. On the other hand, there was strong positive association between consumption of potatoes and IMT of ccca (b-coefficient=0.106, p<0.001).
Conclusions: The existence of different dietary patterns was associated, positively or negatively, with body weight and waist circumference in postmenopausal women. Mediterranean diet is highly protective in modifying indices of obesity among menopausal women. Specific parameters of dietary patterns were strongly related to obesity and vascular function indices.
Main subject category:
Health Sciences
Keywords:
Menopause, Dietary patterns, Obesity, Cardiovascular disease, Mediterranean diet
Number of references:
253
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