The effect of senthaquine and hydroxy ethyl starch on haemorrhagic shock in young swine model.

Doctoral Dissertation uoadl:2819910 197 Read counter

Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
Kontouli Zinais
Dissertation committee:
Χρυσούλα Στάικου, Αν. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Χρυσούλα Μπακούλα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Νικολέττα Ιακωβίδου, Αν. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Αθανασία Τσαρουχά, Επ. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Θεοδώρα Μπούτσικου, Επ. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Γεώργιος Καπαρός, Επ. Καθηγητής, Ιατρική, ΕΚΠΑ
Θεόδωρος Ξάνθος, Καθηγητής, Ιατρική, Πανεπιστήμιο Κύπρου
Original Title:
Η επίδραση της σενθακίνης με υδροξυ-αιθυλάμυλο στην αντιμετώπιση της αιμορραγικής καταπληξίας σε νεαρά χοιρίδια
Translated title:
The effect of senthaquine and hydroxy ethyl starch on haemorrhagic shock in young swine model.
Background: Treatment of hemorrhagic shock includes adequate fluid resuscitation
and colloids have been considered to be four- to five-fold more effective than crystalloids
in expanding blood volume.
Objective: The aim of this study was to investigate the effects of the combination of
centhaquin and 6% hydroxyethyl starch 130/0.4 (HES 130/0.4) in a swine model of
hemorrhagic shock.
Design: Randomized experimental study.
Setting: Academic research center.
Animals: Twenty Landrace-Large White pigs
Intervention: Hemorrhagic shock and resuscitation using either HES 130/0.4 (Group
CO) or HES 130/0.4 plus centhaquin 0.015 mg/Kg (Group CC).
Main outcome measures: All animals were resuscitated until their mean arterial pressure
(MAP) reached 90% of the baseline. The total amount of fluids, time required
achieving the target MAP, 24h survival, and neurological outcome were recorded. In
addition, lung tissue histological analysis and pulmonary capillary leakage determination
was performed.
Results: Although the total amount of the infused HES 130/0.4 was not significantly
different between the two groups (Group CO: 512±37 mL, Group CC: 389±41 mL;
p=0.204), the time required to reach the target MAP was significantly shorter in the centhaquin
group compared to controls (13.7±0.4 min vs. 19.6±0.84 min, p=0.012). During
the resuscitation phase, a statistical significant difference was observed in MAP
(75.2±1.6mmHg vs. 89.8±2.1 mmHg, p=0.02) between Group CO and Group CC. During
the observation phase, a statistical significant difference was observed in SVR
(1109±32.65 vs. 774.6±21.82 dyn.s/cm5, p=0.039) and cardiac output (5.82±0.31 vs.
6.9±0.78 L/min, p=0.027) between the two groups. Two animals of Group CO and seven
animals of Group CC survived for 24 hours (p=0.008). We observed a marked increase
in microvascular capillary permeability in Group CO compared to Group CC, with the wet/dry weight ratio being significantly higher in Group CO compared to
Group CC (4.8±1.6 vs. 3.08±0.6, p<0.001).
Conclusion: The combination of centhaquin 0.015 mg/Kg and HES 130/0.4 resulted in
shorter time to target MAP, lower wet to dry ratio, and better survival rates after resuscitation
from hemorrhagic shock.
Main subject category:
Health Sciences
Hemorrhagic shock, Centhaquin, Hydroxyethyl starch, Survival
Number of index pages:
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