BRAIN EFFECTS OF PREMATURE EXPOSURE TO ENDOCRINE DISRUPTORS ON MICE

Postgraduate Thesis uoadl:2820193 403 Read counter

Unit:
Κατεύθυνση Κλινική Βιοχημεία - Μοριακή Διαγνωστική
Library of the School of Science
Deposit date:
2018-11-23
Year:
2018
Author:
Reisis Efstathios
Supervisors info:
Σταματάκης Αντώνιος, Αναπλ. Καθηγητής Βιολογίας-Βιολογίας Συμπεριφοράς, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Κιτράκη Ευθυμία, Καθηγήτρια Βιολογίας,Τμήμα Οδοντιατρικής, ΕΚΠΑ
Ευθυμιόπουλος Σπυρίδων, Καθηγητής Φυσιολογίας Ζώων & Ανθρώπου – Νευροβιολογίας, Τμήμα Βιολογίας, ΕΚΠΑ
Original Title:
ΕΠΙΠΤΩΣΕΙΣ ΣΤΟΝ ΕΓΚΕΦΑΛΟ ΠΡΩΙΜΗΣ ΕΚΘΕΣΗΣ ΜΥΩΝ ΣΕ ΕΝΔΟΚΡΙΝΙΚΟΥΣ ΔΙΑΤΑΡΑΚΤΕΣ
Languages:
Greek
Translated title:
BRAIN EFFECTS OF PREMATURE EXPOSURE TO ENDOCRINE DISRUPTORS ON MICE
Summary:
Phthalates are industrial chemicals and have long been a part of everyday life as they exist in a variety of consumer products such as textiles, food packaging, plastics, pharmaceuticals, toys, cosmetics. They are mainly used as plasticizers, in the form of phthalate esters. The effects of exposure to phthalates on human health have not been studied well. Animal studies have, however, raised serious concerns about the potential for adverse effects in humans. Phthalates can act as endocrine disrupters, imitating or inhibiting the function of the organism’s normal hormones, thus having adverse effects such as reduced fertility, malformations of the Reproductive System especially in boys, and direct and primary effects on the progression of normal fetal development due to effects on the brain. The present work is an attempt to better understand how the brain, and by extension the whole organism, is affected in these early stages if exposed to phthalates, by examining areas of interest such as the preoptic area of the hypothalamus, the striatum body and somatosensory cortex.
Main subject category:
Science
Keywords:
Endocrine Disruptors, Estrogen Receptors,Androgen Receptor, Phthalates
Index:
Yes
Number of index pages:
2
Contains images:
Yes
Number of references:
106
Number of pages:
95
Επιπτώσεις στον εγκέφαλο πρώιμης έκθεσης μυών σε ενδοκρινικούς διαταράκτες Ρεΐσης Ευστάθιος ΑΜ 61614 τελικο.pdf (2 MB) Open in new window