Diagnostic value of fecal biomarkers in children with diarrhea

Postgraduate Thesis uoadl:2820350 404 Read counter

Unit:
Κατεύθυνση Κλινική Παιδιατρική & Νοσηλευτική - Έρευνα
Library of the School of Health Sciences
Deposit date:
2018-11-25
Year:
2018
Author:
Mitrogiorgou Marina
Supervisors info:
Παπαευαγγέλου Βασιλική, Καθηγήτρια, Ιατρική Σχολή ΕΚΠΑ
Μίχος Αθανάσιος, Αναπληρωτής καθηγητής, Ιατρική Σχολή ΕΚΠΑ
Τζουμάκα-Μπακούλα Χρυσάνθη, Ομότιμη καθηγήτρια, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Η διαγνωστική αξία των βιοδεικτών των κοπράνων σε παιδιά με διάρροια
Languages:
Greek
Translated title:
Diagnostic value of fecal biomarkers in children with diarrhea
Summary:
Introduction: Acute gastroenteritis is one of the most common infections in childhood. The differential diagnosis between viral and bacterial gastroenteritis is difficult, resulting in delay treatment of patients. Calprotectin is the first fecal biomarker used to diagnose and monitor patients with inflammatory bowel disease.
Purpose: Differential diagnosis of viral and bacterial aetiology of acute gastroenteritis in children according to fecal biomarkers (calprotectin, lactoferrin, S100A12)
Material and Method: Prospective study conducted from 01/2017 to 03/2018. Epidemiological and clinical data was collected from patients and controls. Fecal biomarkers were measurement using enzyme-linked immunosorbent assay (ELISA)
Results: Thirty-seven patients with known diagnosis of acute gastroenteritis and thirty-seven healthy controls of the same age were included. Viral gastroenteritis waw diagnosed in 62% of patients. Boys exceeded girls (58.8%). The concentration of calprotectin, lactoferrin and S100A12 in faeces was higher in patients vs control (p <0.0001), while C-reactive protein value was non-statistically significant (p = 0.27). Only fecal S100A12 was found to be significantly different between children with viral and bacterial gastroenteritis. Positive value of S100A12 (≥10μg / g) was associated with a 2-fold risk (RR: 2.20, 95% CI 1.18-4.10) for gastroenteritis overall and a 10-fold risk (RR:10.23, 95% CI 1.88-55.64) for bacterial gastroenteritis but was found to be non- significant for viral gastroenteritis.
Conclusion: All fecal biomarkers studied were sensitive in diagnosing acute gastroenteritis in children. Among these biomarkers , S100A12 appears to be the most reliable indicator of the aetiology of acute gastroenteritis in children.
Main subject category:
Health Sciences
Keywords:
S100A12, Calprotectin, Lactoferrin, Gastroenteritis, Inflammatory bowel disease
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
82
Number of pages:
61
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