The role of exercise in the middle aged in life expectancy and premature morbidity in Drosophila melanogaster

Postgraduate Thesis uoadl:2820360 177 Read counter

Unit:
Κατεύθυνση Μοριακή και Εφαρμοσμένη Φυσιολογία
Library of the School of Health Sciences
Deposit date:
2018-11-28
Year:
2018
Author:
Gotsopoulou Antigoni
Supervisors info:
Χρήστος Κόνσουλας, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Αναστάσιος Φιλίππου, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Μιχαήλ Κουτσιλιέρης, Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Ο ρόλος της άσκησης κατά τη μέση ηλικία στο προσδόκιμο ζωής και την προθανάτια νοσηρότητα στη Drosophila melanogatser
Languages:
Greek
Translated title:
The role of exercise in the middle aged in life expectancy and premature morbidity in Drosophila melanogaster
Summary:
Aging is an inevitable biological phenomenon for every living organism. One of the most important age-dependent changes that occur to people during aging is the progressive reduction in their motor skills including the ability to walk. Good mobility is crucial to maintaining quality of life, so their independence is based on intact motor skills.
In humans, exercise in middle age is desirable. It has been shown that exercise not only improves the muscular strength and mobility but also affects positively the mental health and socialization. However, high exercise intensity and long duration may produce opposite effects. The ideal exercise recipe is not found yet, due to the large heterogeneity among individuals and it is difficult to correlate exercise and longevity.
In order to avoid numerous, uncontrollable environmental, genetic and pathophysiological parameters, we use the genetic model Drosophila melanogaster to study the effect of middle-aged exercise on life expectancy and on the duration and intensity of pre-death malfunctions.
This study is experimental and concerns adult male Drosophila melanogaster of the Oregon-R wild-type series. The purpose of this paper is to investigate the role of exercise in middle age on lifespan duration of Drosophila melanogaster.
Methods:
 Growth of populations (10 male individuals / vial) whose individuals have been identified with regard to their date of birth.
 Separation of individuals according to their age (43 days and 57 days).
 Applying the exercise to three groups (witness group - group participating in a half-hour exercise - group participating in a 2.5-hour exercise). Exercise involves triggering the risk escape reflex. The reflex will be triggered by a mechanical stimulus (sharp impact of the vials on a hard surface).
 Observation of individuals on the vials and daily recording of deaths.
The duration of the experimental procedure was 7 days.
The results of the experiments showed that Drosophila melanogaster middle and late adulthood exercise does not affect or even has a negative impact on its lifespan.
Main subject category:
Health Sciences
Keywords:
Exercise, Drosophila Melanogaster, Middle Age, Life Expectancy
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
113
Number of pages:
60
Ο ρόλος της άσκησης κατά τη μέση ηλικία στο προσδόκιμο ζωής και την προθανάτια νοσηρότητα στη Drosophila melanogaster-converted.pdf (980 KB) Open in new window