Neutrophil to Lymphocyte Ratio (NLR) and Pregnancy Outcomes in natural conception and in medically assisted reproduction (MAR): a case-control study.

Postgraduate Thesis uoadl:2820731 433 Read counter

Unit:
Κατεύθυνση Έρευνα στην Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences
Deposit date:
2018-11-29
Year:
2018
Author:
Christoforaki Viktoria
Supervisors info:
Χαράλαμπος Συριστατίδης, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Μαστοράκος Γεώργιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Σαλαμαλέκης Γεώργιος, Διδάκτωρ, Ιατρική, ΕΚΠΑ
Original Title:
Ο λόγος των ουδετεροφίλων προς τα λεμφοκύτταρα σαν παράγοντας έκβασης της εγκυμοσύνης μετά από αυτόματη σύλληψη και μετά από εξωσωματική γονιμοποίηση. Μια αναδρομική ανάλυση.
Languages:
Greek
Translated title:
Neutrophil to Lymphocyte Ratio (NLR) and Pregnancy Outcomes in natural conception and in medically assisted reproduction (MAR): a case-control study.
Summary:
First Trimester Neutrophil to Lymphocyte Ratio (NLR) and Pregnancy Outcomes in natural conception: a case-control study.
Abstract
Background/aim: In early pregnancy, spontaneous abortion is the most common complication. The early identification of women at high risk for miscarriage could improve pregnancy outcomes. We investigated whether the first trimester neutrophil to lymphocyte ratio (NLR) could be used as a prognostic marker for spontaneous abortion in pregnancies after spontaneous conception.
Patients and Methods: We retrospectively identified 129 pregnant women who had a first trimester full blood count available and known pregnancy outcome. First trimester NLR was calculated for each woman and mean NLR was compared between women with uncomplicated pregnancies/live births and those with spontaneous abortion.
Results: NLR was not found significantly different between the two groups (2.5±1.0 vs. 2.9±1.5, p=0.167) and did not affect pregnancy outcome. NLR values >5.8 were exclusively associated with spontaneous abortion (p=0.028).
Conclusion: First trimester NLR values are similar between women with live birth or spontaneous abortion, after natural conception. Values of NLR higher than 5.8 have been associated with spontaneous abortion.
First Trimester Neutrophil to Lymphocyte Ratio (NLR) and Pregnancy Outcomes in medically assisted reproduction (MAR): a case-control study.

ABSTRACT
Introduction: The success rates of in vitro fertilization (IVF) treatments have improved dramatically over the recent years and depend on different parameters such as the cause of infertility, maternal age, the reproductive and medical history of the participants, lifestyle factors, the physician’s capacity to make correct diagnosis, the laboratory methods used and several technical issues. Several markers have been proposed to predict IVF outcome in an attempt to save time, money, physical and emotional effort. Measuring haematological parameters such as the neutrophil to lymphocyte ratio (NLR) might help predict IVF outcome.
Objective: To evaluate whether NLR as a biomarker for systemic inflammation could be used as a reliable marker for IVF success
Materials and Methods: We identified infertile women who underwent IVF between November 2004 and February 2017 in the University Hospital of Athens, Greece. From the patients’ records we extracted full blood counts at the time of the oocyte retrieval. NLR was calculated and demographic, clinical and haematological parameters were compared between women who failed and those who succeeded in conceiving.
Results: We identified 66 women who underwent IVF; of them 35 failed to conceive and 31 had viable pregnancies. There was no statistically significant difference between the two groups in demographic, clinical and IVF parameters. Higher OR’s of IVF success were detected only at higher NLR ratios, when NLR is divided into quartiles and only in the 4th quartile (OR: 4.33 (95%CI: 1.02-10.79)). A tendency for IVF success was revealed in women of age group 35-38 with an OR of 9.00 ((0.99-81.93) (p=0.051) in comparison to the younger women’s group (<=29 years old). This tendency might be attributed to positive correlation between NLR and age (r=0.310, p=0.011 and rs=0.363, p=0.033).
Main subject category:
Health Sciences
Keywords:
NLR, Abortion, IVF
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
109
Number of pages:
76
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