Κατεύθυνση Σακχαρώδης Διαβήτης και Παχυσαρκία
Library of the School of Health Sciences

2018-11-29

2018

Athanasoulia Kleio-Maria

Τεντολούρης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μακρυλάκης Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κόκκινος Αλέξανδρος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Η παχυσαρκία και ο σακχαρώδης διαβήτης στο σύνδρομο Prader-Willi. – Συστηματική ανασκόπηση των κλινικών μελετών που αφορούν το σακχαρώδη διαβήτη και την αντιμετώπισή του, σε ενήλικες ασθενείς με σύνδρομο Prader-Willi, με αφορμή περιστατικό μεσήλικος ανδρός

Greek

Obesity and diabetes mellitus in Prader-Willi syndrome. - A Systematic review of clinical trials on diabetes mellitus and its treatment in adult patients with Prader-Willi syndrome, on occasion of a middle-aged man

Prader-Willi syndrome (PWS) is a relatively common genetic disorder. About ¼ of adult patients with the syndrome, suffer from type 2 diabetes mellitus (DM) and obesity. Due to existence of several comorbidities and the complex pathophysiology of the syndrome, appropriate DM treatment in these patients requires further verification. A systematic review of trials in adults with PWS that include patients with DM or study glucose metabolism factors, has been performed for this purpose. Only very few trials have been found, concerning mostly growth hormone treatment or exenatide administration. The majority of them was of short duration with a limited number of participants. As a conclusion, current evidence does not support the utilization of different medical treatment for DM in patients with PWS in comparison to DM patients without the syndrome. However, due to multiple confounding factors, further larger multicentre trials need to be organized to study possible effects of current and new treatment options for PWS on glucose metabolism.

Health Sciences

Prader-Willi syndrome, Diabetes mellitus, Obesity

No

0

Yes

128

75

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/2820748