Immunological laboratory criteria of allergic bronchopulmonary aspergillosis in children with cystic fibrosis disease

Doctoral Dissertation uoadl:2836977 316 Read counter

Unit:
Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences
Deposit date:
2006
Year:
2017
Author:
Katelari Anna
Dissertation committee:
1. Εμμανουήλ Καναβάκης, Καθηγητής Ιατρικής Γενετικής, Ιατρικής Σχολής Ε.Κ.Π.Α., Επιβλέπων, μέλος Δ.Ε.Π.
2. Μαρία Παπαγρηγορίου-Θεοδωρίδου, Καθηγήτρια Παιδιατρικής και Λοιμώξεων, Ιατρικής Σχολής Ε.Κ.Π.Α.
3. Χριστίνα Κανακά-Gantenbein, Καθηγήτρια Παιδιατρικής Ενδοκρινολογίας, Ιατρικής Σχολής Ε.Κ.Π.Α.
4. Νικόλαος Κουλούρης, Καθηγητής Πνευμονολογίας, Ιατρικής Σχολής Ε.Κ.Π.Α.
5. Σοφία Κίτσιου-Τζέλη, Καθηγήτρια Ιατρικής Γενετικής, Ιατρικής Σχολής Ε.Κ.Π.Α.
6. Βιολέττα Καψιμάλη-Βαϊοπούλου, Αν. Καθηγήτρια Μικροβιολογίας και Ανοσολογίας, Ιατρικής Σχολής Ε.Κ.Π.Α.
7. Λεωνίδας Τζουβελέκης, Αν. Καθηγητής Μικροβιολογίας, Ιατρικής Σχολής Ε.Κ.Π.Α.
Original Title:
Ανοσολογικά εργαστηριακά κριτήρια της αλλεργικής βρογχοπνευμονικής ασπεργίλλωσης σε παιδιά με ινοκυστική νόσο
Languages:
Greek
Translated title:
Immunological laboratory criteria of allergic bronchopulmonary aspergillosis in children with cystic fibrosis disease
Summary:
Background: Allergic bronchopulmonary aspergillosis (ABPA) and Aspergillus fumigatus sensitization (AFS) quite often are observed in cystic fibrosis (CF) patients. The aim of this study was to evaluate the use of basophil activation test (BAT) in these manifestations of hypersensitivity reactions. Methods: BAT (CD63 and CD203c) was performed for 56 CF patients (17 ABPA, 24 AFS and 15 non-AFS). A receiver operating characteristic (ROC) curve analysis and a survival analysis were performed. Results: Both markers significantly contributed in ABPA diagnosis (P value b 0.001 for both). Twelve AFS patients fulfilled the criteria for ABPA diagnosis during the follow-up period. The median time to ABPA diagnosis was 9 months for patients whose values were over the best cutoffs (P value < 0.001 for both). Conclusions: BAT could be considered as an additional criterion for ABPA diagnosis in CF as well as a potential marker for the monitoring of patients with AFS.
Main subject category:
Medicine
Keywords:
Cystic fibrosis
Index:
No
Number of index pages:
4
Contains images:
Yes
Number of references:
781
Number of pages:
279
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