Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Μαριάννα Πολίτου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αργυρή Γιαλεράκη, Επίκουρος Καθηγήτρια, Ιατρική Σχολή, ΕΠΚΑ
Νικόλαος Βλάχος, Καθηγητής, Ιατρική Σχολή, ΕΠΚΑ
Γενετικοί πολυμορφισμοί που επηρεάζουν την έκβαση της κύησης
Genetic polymorphisms affecting the pregnancy outcome
Pregnancy is a hypercoagulable state, caused by the physiological changes occurring in the haemostatic system in order to protect the pregnant woman from severe bleeding during childbirth. The successful outcome of pregnancy depends on the development and maintenance of adequate placental circulation. Disturbances in placental circulation can cause various adverse outcomes in pregnancy, such as pregnancy loss, endometrial death, preeclampsia, placental abruption, premature labor and intrauterine growth retardation.
The pathogenetic mechanisms leading to placental circulation disorders have not been fully elucidated. The probability there are genetic factors that affect the outcome of pregnancy has led to the investigation of many genetic polymorphisms and their possible correlation with pregnancy complications. Many genes involved in clotting, metabolism, immune response, angiogenesis have been studied. However, the results of several studies are contradictory and the pathogenicity of pregnancy complications remains unclear. Therefore, further investigation and study of genetic polymorphisms affecting the outcome of pregnancy is required to be used as prognostic indicators to provide better prenatal care and treatment when needed to avoid complications and ensure successful outcome of pregnancy.
Main subject category:
Genetic polymorphisms, Pregnancy complicatiosn, Thrombofilia
Liakou Panagiota Master.pdf
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