Risk factors of hyperemesis gravidarum: a systematic review

Postgraduate Thesis uoadl:2837831 327 Read counter

Unit:
ΠΜΣ Έρευνα στη Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences
Deposit date:
2018-12-17
Year:
2018
Author:
Ioannidou Pinelopi
Supervisors info:
Δημήτριος Γ.Γουλής, Αναπληρωτής Καθηγητής, Ιατρική, ΑΠΘ
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική, ΕΚΠΑ
Θεμιστοκλής Μίκος, Επίκουρος Καθηγητής, Ιατρική, ΑΠΘ
Original Title:
Παράγοντες κινδύνου για την υπερέμεση κύησης: συστηματική ανασκόπηση
Languages:
Greek
Translated title:
Risk factors of hyperemesis gravidarum: a systematic review
Summary:
Background: Hyperemesis gravidarum (HG) is the main cause of hospitalization during the first trimester of pregnancy. Although it has been associated with serious complications, little is known about its predictive factors. The aim of this systematic review was to search for and critically appraise the studies that investigate the predictive factors for HG.
Patients and Methods: A systematic search was performed by two reviewers on PubMed (MEDLINE), CENTRAL (Cochrane) and EMBASE. No restrictions regarding publication date and language were implied. Screening of available studies was carried out by two reviewers, as well as the quality assessment of the included studies, based on the Newcastle-Ottawa Scale for observational studies.
Results: The search located308 articles, of which 14 observational studies (four low-, eight medium- and two high-quality) involving 1400 women met the eligibility criteria. In four studies, there was no association between Helicobacter (H.) Pylori infection and HG, in contrast to two studies which demonstrated such an association. Pre-pregnancy body mass index (BMI), adipose tissue, maternal age, leptin, ghrelin, beta-chorionic gonadotropin (β-hCG), total (T4) and free thyroxine(fT4) correlated with HG in various studies and could be considered as predictive markers. Regarding the high-quality evidence, a cohort study associated leptin and nephatin-1 with HG, whereas across-sectional study found no association between H. pylori infection and HG.
Conclusions: More studies of high quality and adequate sample size have to be carried out to identify the predictive factors for HG.
Main subject category:
Health Sciences
Keywords:
Risk factors, Hyperemesis gravidarum
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
101
Number of pages:
91
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