Percutaneous CT guided thermal ablation with RF and MW for the treatment of metastases from Non Small Cell Lung Cancer

Postgraduate Thesis uoadl:2838514 287 Read counter

Unit:
Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences
Deposit date:
2018-12-28
Year:
2018
Author:
Tavernaraki Kyriaki
Supervisors info:
Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Σοφία Χατζηιωάννου, Αναπλ. Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γαρυφαλλιά Πουλάκου, Επικ. Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Αντιμετώπιση μεταστάσεων από Μη Μικροκυτταρικό Καρκίνο Πνεύμονα με διαδερμική, υπό αξονικό τομογράφο, θερμοκαυτηρίαση με RF και MW
Languages:
Greek
Translated title:
Percutaneous CT guided thermal ablation with RF and MW for the treatment of metastases from Non Small Cell Lung Cancer
Summary:
Introduction

Patients with NSCLC and metastatic disease limited in number and location have better prognosis and may benefit from local treatments. Percutaneous CT guided thermal ablation is an alternative, minimally invasive method for the treatment of adrenal metastases, painful bone metastases and liver metastases originating from NSCLC.
Purpose

The purpose of this retrospective study is the evaluation of safety and efficacy of CT guided thermal ablation (RFΑ and MWΑ) in the management of adrenal metastases, painful bone metastases and liver metastases from NSCLC. Patients and Methods
A total of 142 patients with metastatic NSCLC (71 patients with adrenal metastases, 32 patients with painful bone metastases and 40 patients with liver metastases) who were treated with CT guided RF and MW ablation were retrospectively studied. The efficacy of thermal ablation was evaluated by post ablation imaging. For painful bone metastases, palliation was assessed by BPI score.
Results

Technical success of CT guided thermal ablation was 100%. No major complications occurred.
For adrenal metastases, local recurrence was observed in up to 22.8% in the 6month follow up and up to 19.4% in one year.

For painful bone metastases, a significant pain relief was observed after the thermal ablation.
For liver metastases, local recurrence was observed in 8.2% in the 6month follow up and in 3.3% in the annual follow up.
Conclusion

CT guided RF and MW ablation is a safe and effective local treatment for the management of adrenal, bone and liver metastases from NSCLC. For painful bone metastases in particular, RF ablation provides significant pain relief. As a minimally invasive technique, thermal ablation in selected patients is a promising, alternative method for the local treatment of NSCLC metastases.
Main subject category:
Health Sciences
Keywords:
Lung cancer, Metastases, Thermal ablation, Computed Tomography, Radiofrequency, Microwave
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
64
Number of pages:
103
File:
File access is restricted only to the intranet of UoA.

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