ΠΜΣ Παθολογία της Κύησης
Library of the School of Health Sciences

2019-01-04

2018

Tasiopoulou Ioanna

Παπαντωνίου Νικόλαος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ
Κασσάνος Δημήτριος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ
Χρέλιας Χαράλαμπος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ

Επινεφρίδια και κύηση

Greek

Adrenal glands and pregnacy

Adrenal insufficiency (AI) is very rare in pregnancy, and the exact prevalence is unknown. AI can present acutely or with a more insidious set of chronic symptoms. Primary AI (so-called Addison’s disease) refers to intrinsic adrenal pathology with atrophy of the adrenal cortex and insensitivity to ACTH and angiotensin II stimulation, resulting in impairment of aldosterone and/or cortisol secretion. Urinary and plasma cortisol and aldosterone levels are low or undetectable. Plasma aldosterone-to-renin ratios are reduced in association with elevated PRA. Secondary or tertiary AI arises from impaired ACTH or CRH secretion due to hypothalamic or pituitary disease or, more commonly, as a result of exogenous corticosteroid administration. However, secondary AI is not associated with mineralocorticoid deficiency. Intrauterine growth retardation and low birth weight are the most commonly reported adverse effects for the fetus from mothers with untreated AI also an increased risk of maternal mortality, which was eliminated by the timely and appropriate glucocorticoid replacement treatment.

Health Sciences

Glucocorticoid, Adrenal insufficiency, Adrenal glands, Pregnancy, Aldostrone, Renin, Autoimmune disease

No

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Yes

51

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https://pergamos.lib.uoa.gr/uoa/dl/object/2838645