Unit:
Library of the School of Health SciencesΚατεύθυνση Κλινική Νοσηλευτική: Χειρουργική Νοσηλευτική
Author:
Tsipoliti Georgia-Elpida
Supervisors info:
Ελένη Θεοδοσοπούλου, Καθηγήτρια, Τμήμα Νοσηλευτικής, ΕΚΠΑ, Επιβλέπουσα
Κωνσταντίνος Τσουμάκας, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Θεόδωρος Μαριόλης- Σαψάκος, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Original Title:
Μελέτη λειτουργίας του ήπατος με εκτίμηση των ενζύμων και των πρωτεϊνών σε ασθενείς με ασκιτική συλλογή ανάλογα με τη νόσο
Translated title:
The assesment of liver function, through the evaluation of enzymes and proteins, in patients with ascitic collection depending on the existing disease
Summary:
Introduction-Background: Ascites are abnormal build-up fluid in the abdomen. The most common cause of ascites collection is cirrhosis of the liver.
Aim: The assessment of liver function, through the evaluation of enzymes and proteins, in patients with ascetic collection depending on the existing disease.
Methods: This prospective cohort study was performed in one medical ward of one Public Hospital in Athens during December 2016 - July 2018. For the collection of the data a special form was created in which the demographic, clinical and laboratory data of the patients were recorded. The collection of data was carried out through the study of patients' medical records. The sample of the study consisted of 49 adult patients with liver disease and ascites. Descriptive statistics and correlation study were carried out using SPSS 24.0 (p≤0.05).
Results: The mean age of the patients was 59.9 (± 13.2) years and 67.3% of the patients were male. 36.7% of the patients had alcoholic liver disease, 30.6% viral hepatopathy and 12.2% non-alcoholic liver disease. 47.9% of patients died. The mean SOFA score was 4.93 (± 2.73) and 26.4% of patients had a GCS 11-13. 40.8% of patients had a moderate ascites collection and 59.2% large / resistant ascites. 63.8% of patients were in stage C according to the Child-Pugh scale. Patients had elevated levels of liver enzymes SGOT, SGPT, LDH, γ-GT, and total and direct bilirubin. Also, patients had reduced the levels of albumin. Patients had extended the prothrombin time, the partial thromboplastin time and had elevated the D-dimer levels. Patients with cirrhosis of the liver had significantly higher albumin levels in ascitic fluid (p = 0.003) and serum D-dimer levels (p = 0.005) than patients without cirrhosis of the liver. The male / female ratio was significantly higher in patients with alcoholic liver disease than in patients with ascites due to viral or non-alcoholic liver disease (p = 0.017). There was no statistically significant difference in protein and enzyme levels between patients with different ascites collection, with the exception of LDH (p = 0.046) and ferritin (p = 0.040).
Conclusions: Data show that patients with ascites collection and liver disease are characterized by hepatic dysfunction. Enzyme and protein levels are similar to existing disease, with the exception of LDH and ferritin
Main subject category:
Health Sciences
Keywords:
Ascites, Enzymes, Liver function, Proteins.
