Epidimiology and clinicopathological characteristics of Gastrointestinal Stromal Tumours: A single center experience

Postgraduate Thesis uoadl:2846932 93 Read counter

Unit:
Κατεύθυνση Χειρουργική Ογκολογία
Library of the School of Health Sciences
Deposit date:
2019-01-28
Year:
2019
Author:
Stefanou Ioannis
Supervisors info:
Κωνσταντίνος Γ. Τούτουζας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Δημήτριος Θεοδώρου, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Αλεξάκης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επιδημιολογικά, κλινικά και παθολογοανατομικά χαρακτηριστικά GIST. Η εμπειρία ενός τριτοβάθμιου Νοσοκομείου
Languages:
Greek
Translated title:
Epidimiology and clinicopathological characteristics of Gastrointestinal Stromal Tumours: A single center experience
Summary:
This study, entitled: “Epidimiology and clinicopathological characteristics of Gastrointestinal Stromal Tumours: A single center experience” is a retrospective analysis of patients operated in our hospital from March 2007 to October 2017. We reviewed the data from 87 patients including age, gender, pathology reports and the clinical presentation of these 87 cases. Diagnosis was confirmed either by biopsy or after the surgical resection of the tumor. We also reviewed the radiologic findings and especially the extent of the lesion, the estimated operability and multi-organ involvement. Intraoperative details, including the extent and completeness of the resection were also analyse. Apart from this we performed a literature search (Scopus, Medline, Pubmed) concerning the gastrointestinal stromal tumors, in order to compare our findings to those previously reported. We surprisingly found that this study was one of the largest case series of a single center reported so far.
It is generally known that, there is a large clinical and histological variability among GIST cases. In this study, the main characteristics of our patients were similar to those previously reported. Despite that, when categorizing tumors by site, the immunohistochemical features of GISTs of different sites could not be compared, due to the small number of cases in certain cites; this is also true for the differential diagnostic implications of the possible heterogeneity of GISTs that was not systematically explored, again due to the small number of reported cases. There were however significant immunohistochemical differences in the stomach GIST group concerning the frequency of expression of the CD34 antigen. We think that awareness of the immunohistochemical spectrum of GIST at different sites and identification of the immunoreactivity patterns of these tumors may lead to the use of better diagnostic tools, thus eliminating diagnostic pitfalls. Finally, new molecular biology studies and further investigation of the genomic profile of these tumors are needed, in order to establish novel therapeutic strategies
Main subject category:
Health Sciences
Keywords:
Gastrointestinal stromal tumors, c-KIT, PDGFRA, Surgical oncology, Epidimiology, Immunohistochemistry
Index:
Yes
Number of index pages:
1
Contains images:
Yes
Number of references:
133
Number of pages:
43
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