Pathological Anatomy Study of Placenta in intrauterine fetal deaths of second and third Trimester.Retrospective study 15 years.

Doctoral Dissertation uoadl:2850889 198 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2019-02-04
Year:
2019
Author:
Mantakas Xenofon
Dissertation committee:
Ευθύμιος Δεληγεώρογλου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Βλάχος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Γούτας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτρης Βλαχοδημητρόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτης Βάκας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λέων Αραβαντινός, Επίκουρος Καθηγητής, Ιατρική Σχολή,ΕΚΠΑ
Θεόδωρος Πανοσκάλτσης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Παθολογοανατομική μελέτη του πλακούντα σε ενδομήτριους θανάτους 2ου και 3ου τριμήνου κυήσεως. Αναδρομική μελέτη 15 ετών.
Languages:
Greek
Translated title:
Pathological Anatomy Study of Placenta in intrauterine fetal deaths of second and third Trimester.Retrospective study 15 years.
Summary:
Introduction: Stillbirth is always a sudden and painful event for parents and obstetrical specialists as well. It is, therefore, of greatest importance to be able to give answers for the cause in order to plan another pregnancy.
Materials and methods: The aim of this retrospective study was to estimate the placental and umbilical cord cause of intrauterine death in relation to different gestational ages. The study took place on the Medical Birth Registry of Aretaieio Hospital, National and Kapodistrian University, Athens, Greece. We excluded pharmaceutical abortions and those containing vague variables. The macro/microscopic examination was performed by a pathologist specialized in embryonic medicine. We selected the ReCoDe 2005(relevant condition of death) which best-corresponded on the findings of our laboratory.
Results: We include a total of 19,283 pregnancies from 1998 to 2012. In this study period 431 embryonic deaths occurred. The clinical history was documented on admission at delivery. Conditions thought to be associated with the intrauterine fetal death were recorded. Gestational age was calculated from the last menstrual period as well as with the three-trimester system. The autopsy and placenta and umbilical cord examination were performed by the same laboratory of pathology in Aretaieio University Hospital. We found that the majority of stillbirths occurred the second trimester. We examined placenta and umbilical cord in all cases. The major frequent histologic abnormalities were those indicated placental vascular insufficiency. As far as umbilical cord is concerned we found that the inflammatory disorder was the most common in antepartum deaths. Single umbilical artery was significantly related with gestational diabetes and congenital embryonic anomalies.
Conclusions:Finally, our results showed steady declines in antepartum deaths during 1998-2012. As a result we reached the conclusion that to reduce the fetal death rate, we have to insist on autopsy of placenta and umbilical cord in order to gain the appropriate information in counselling the parents.
Main subject category:
Health Sciences
Keywords:
Stillbirth, Anterpartum deaths, Placenta, Umbilical cord
Index:
Yes
Number of index pages:
0
Contains images:
Yes
Number of references:
63
Number of pages:
148

Mantakas Xenofon PhD.pdf
2 MB
File access is restricted only to the intranet of UoA.