Τhe association between ovarian volume, sex hormones and bone metabolism in postmenopausal women.

Doctoral Dissertation uoadl:2854563 68 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2019-02-06
Year:
2019
Author:
Tsitoura Anastasia
Dissertation committee:
Δεληγεώρογλου Ευθύμιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καλανταρίδου Σοφία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λαμπρινουδάκη Ειρήνη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βάκας Παναγιώτης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πανουλής Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αραβαντινός Λέων, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Μιχαλά Σταυρούλα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η συσχέτιση των μορφολογικών υπερηχογραφικών χαρακτηριστικών της εμμηνοπαυσιακής ωοθήκης με τα ενδογενή στεροειδή του φύλου και τον οστικό μεταβολισμό
Languages:
Greek
Translated title:
Τhe association between ovarian volume, sex hormones and bone metabolism in postmenopausal women.
Summary:
Introduction: Menopause consists of the cessation of the menstrual cycle
caused by ovarian failure and leads to estrogen deficiency. The consequent
hormonal imbalance is linked to short-term disturbances like the climacteric
symptoms but also to long-term consequences. The ovarian size declines
steadily after the menopausal transition, and any variance in the size is of
concern mostly for the risk of neoplasia.
Aim: The present study aimed to assess the association between ovarian
volume and demographic and anthropometric parameters, as well as sex
hormones and bone mineral density (BMD) in postmenopausal women.
Methods: 161 healthy postmenopausal women participated in this crosssectional
study. Fasting venous blood samples were obtained for
biochemical/hormonal assessment. Anthropometric parameters included body
mass index (BMI) and waist-to-hip ratio (WHR). Ultrasonography was used to
estimate the average ovarian volume for each participant. BMD was
measured in the femoral neck (FN) and the lumbar spine (LS) using DXA.
Results: Mean ovarian volume increased linearly with increasing quartiles of
BMI (Q1:0.985±0.25, Q2: 1.11±0.29, Q3: 1.07±0.28, Q4: 1.19±0.38, p-value
for linear trend 0.013). Ovarian volume correlated positively with BMI
(r=0.128, p-value=0.038), FN BMD (r=0.233, p-value=0.003), FN T-score
(r=0.223, p-value=0.004) and FN Z-score (r=0.171, p-value=0.027).
Multivariate analysis showed that ovarian volume was predicted by WHR (bcoefficient=
0.157, p-value=0.047) and SHBG (b-coefficient= -0.160, pvalue=
0.042), independently of age and BMI. Finally, FN BMD was predicted
by ovarian volume, independently of age, menopausal age and BMI.
Conclusion: Ovarian volume was positively and independently associated
with adiposity indexes and femoral BMD in postmenopausal women. Lower
SHBG levels were associated with higher ovarian volume. Insulin resistance
may mediate these results. The significance of these findings should be
assessed in larger prospective studies.
Main subject category:
Health Sciences
Keywords:
Ovarian volume, Menopause, Bone mineral density
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
273
Number of pages:
140
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