Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Author:
Kyriakaki Stavroula
Supervisors info:
Παπαδάκη Ελένη, Καθηγήτρια, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Πολίτου Μαριάννα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Τραυλού Ωραιάνθη, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Θαλασσαιμία και θρόμβωση
Translated title:
Thalassemia and thrombosis
Summary:
The thalassemias, a group of inherited disorders of hemoglobin synthesis, are the most common monogenetic disease worldwide caused by defective globin synthesis resulting in decreased quantity of globin chains.
Although the life expectancy of thalassemia patients has markedly improved over the last few years (amelioration of transfusion regimens as well as improvement in monitoring and management of iron overload), patients still suffer from many complications of this congenital disease.
Both venous and arterial events, including rare thrombotic episodes in the brain, have been described with a higher incidence of thalassemia than thalassemia major patients.
The presence of a high incidence of thromboembolic events has led to the identification of a hypercoagulable state in these patients. In particular, significant hemostatic anomalies, even from a very young age, were observed in patients with major β-thalassemia and intermediate β-thalassemia and also in patients with α-thalassemia (hemoglobin H disease).
In this paper, we review the molecular and cellular mechanisms leading to hypercoagulability in thalassemia.
Main subject category:
Health Sciences
Keywords:
Thalassemia, Thrombosis, Thromboembolic events
Number of references:
151
