Unit:
Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και ΕκτέλεσηLibrary of the School of Health Sciences
Supervisors info:
Φλώρα Ζαγουρή, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ευάγγελος Τέρπος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Γαβριατοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος των microRNAs στην πρόγνωση στον καρκίνο του μαστού
Translated title:
The role of microRNAs in breast cancer prognosis
Summary:
Breast cancer is a heterogeneous disease that differs greatly among patients and even within each individual tumor. MicroRNAs (miRNAs) have been found to play an important role in the occurrence and development of human cancers, functioning either as potential oncogenes or tumor suppressor genes, but their role in the prognosis of breast cancer patients remains unclear. The aim of the present review study is to highlight recent preclinical and clinical studies performed on both circulating and tissue-specific miRNAs and their potential role as prognostic markers in breast cancer. We performed a systematic review to explore the prognostic value of miRNAs in breast cancer. We systematically searched the PubMed database to identify eligible studies. After performing the literature search and review, 117 relevant studies were identified. We found that 110 aberrantly expressed miRNAs have been associated with prognosis in breast cancer. In conclusion, miRNAs could serve as novel prognostic tools in breast cancer, while the clinical application of these findings has yet to be verified.
Main subject category:
Health Sciences
Keywords:
Breast cancer, microRNAs, Prognosis, Biomarkers
Number of references:
199
