Pergamos - Library and Information Center of National and Kapodistrian University of Athens

Unit:

Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

Deposit date:

2019-03-22

Year:

2019

Author:

Koliastasis Leonidas

Supervisors info:

Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Π. Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυρίτση Ελένη, Καθηγήτρια, Τμήμα Νοσηλευτικής, Πανεπιστήμιο Δυτικής Αττικής

Original Title:

Σχέση της ενδοθηλιακής δυσλειτουργίας και της ιντερλευκίνης-6 με την ύπαρξη στεφανιαίας νόσου σε ασθενείς με θωρακικό άλγος

Languages:

Greek

Translated title:

Correlation of endothelial dysfunction and interleukin-6 with the presence of coronary artery disease in patients with chest pain

Summary:

Introduction: Endothelial dysfunction and low-grade inflammation are associated with advancement of coronary artery disease (CAD) and may implicated in the progression from stable CAD to acute coronary syndrome (ACS).
Purpose: The correlation of the CAD with the variation of the Interleukin-6 (IL-6) serum levels and FMD in patients with acute chest pain.
Materials and Methods: The total study population consisted of 864 subjects. From 663 presented with chest pain a diagnosis of ACS was attributed in 460. The rest have been characterized as having chest pain of non-ischemic etiology. We additionally recruited 201 consecutive patients with stable CAD. Endothelial function was assessed by flow mediated dilatation (FMD). Interleukin-6 (IL-6) levels were measured with ELISA. ACS subjects were followed-up for major adverse cardiovascular events (MACE).
Results: There was a stepwise impairment in FMD and logIL-6 from patients with chest pain of non-ischemic etiology to stable CAD and to patients with ACS (p<0.001 for FMD and logIL-6). Moreover, patients presented with chest pain have increased odds for ACS, when elevated IL-6 serum levels (ΟR: 3.10, 95% C.I.: 1.92 – 5.00, p<0.001) and impaired FMD (OR: 0.84, 95% C.I.: 0.74 – 0.93, p=0.005) are found.
Conclusion: Patients presented with ACS have endothelial function impairment and increased levels of IL-6. These findings provide possible evidence on the processes preceding plaque rapture and may implement new treatment targets.

Main subject category:

Health Sciences

Keywords:

Acute coronary syndrome, Coronary artery disease, Endothelial function, Inflammation, Pro-inflammatory cytokines, Interleukin

Index:

Number of index pages:

Contains images:

Yes

Number of references:

206

Number of pages:

File: