Unit:
ΠΜΣ Χειρουργική ΟγκολογίαLibrary of the School of Health Sciences
Author:
Zografos Konstantinos
Supervisors info:
Κωνσταντίνος Γ. Τούτουζας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Θεοδώρου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Αλεξάκης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Αναγεννησιακή ικανότητα των ηπατοκυττάρων μετά από ηπατεκτομή
Translated title:
Liver regeneration following hepatectomy
Summary:
Liver regeneration after partial hepatectomy is a medical field that has been extensively studied by clinicians, surgeons, and researchers for decades. Efforts to deeply comprehend the process of regeneration are being made, in order to discover novel therapies for liver failure. However, tissue regeneration is a complex process, controlled by multiple factors, including cytokines, growth factors, and developmental signaling pathways. The aim of the present review is to highlight recent data on liver regenerative response following hepatectomy. In this study we will also discuss the function, physiology and anatomy of liver, present the complex molecular mechanisms of liver regeneration, elucidate the specific mechanisms and regulatory molecules involved in this well-orchestrated process, describe the role of hepatic progenitor cells and elaborate the cellular signaling pathways required to ensure liver restoration.
Main subject category:
Health Sciences
Keywords:
Hepatic progenitor cell, Liver regeneration, Liver failure, Hepatectomy
