Unit:
Διατμηματικό ΠΜΣ Ιατρική Φυσική-ΑκτινοφυσικήLibrary of the School of Health Sciences
Author:
Theodorakou Dimitra
Supervisors info:
Παναγιώτης Παπαγιάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.
Παντελής Καραΐσκος, Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.
Κωνσταντίνος Λουκάς, Επίκουρος Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.
Original Title:
Μελέτη επίδρασης της γεωμετρίας υπολογισμού βασικών δοσιμετρικών δεδομένων πηγής, στο σχεδιασμό βραχυθεραπείας μαστού
Translated title:
Impact study of baseline source dose data calculation geometry in breast brachytherapy design
Summary:
According to relatively recent international recommendations, a 192Ir brachytherapy source (in the formalisation of the TG-43 working group) traditionally conducted in a 15cm (bounded) radial spherical water dome should be used, unlimited, radius> 40cm).
This paper aims to study the effect of the calculation geometry on the breast brachytherapy design.
To do this, we compared dosimetric calculations performed using source-based dosimetric data in limited and unlimited geometry for 39 clinical breast breast shots. The comparison for each shot was done in terms of mapping the percentage differences in selected levels of the anatomy and in terms of comparison of parameters characterizing the quality of the dosimetric design according to the established clinical protocols (homogeneity and compliance of the dose distribution in the target tumor, Dose-Volume Diagram for both the target and the critical organs including the side, lung, skin, heart, and coarse breast). The statistical treatment of the results demonstrated The statistically significant difference in the target volume as the dose at each point therein is determined primarily by the primary radiation from the proximal source to the source dose calculation geometry affects only the dose from scattered radiation.
Non-statistically significant differences were also observed for the same reason in critical instrument parameters close to target volume. Some parameters of critical organs at a greater distance, such as the lung, showed statistically significant differences. However, their order of magnitude was so small that practically they could be considered negligible.
As a conclusion, there are no substantial dosimetric differences in the clinical application studied due to the change in the calculation geometry of the baseline source data from a limited (15-ball) radius to an unlimited (40-ball radius).
Main subject category:
Health Sciences
Keywords:
Brachytherapy, Breast, Geometry, Comparison, Parameters
File:
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Theodorakou Dimitra Master.pdf
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