Correlation of ectopic fat infiltration of liver and muscles with atherosclerosis burden in peripheral arteries

Postgraduate Thesis uoadl:2876391 265 Read counter

Unit:
Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences
Deposit date:
2019-06-20
Year:
2019
Author:
Angelopoulos Andreas
Supervisors info:
Τούσουλης Δημήτριος, Καθηγητής, Ιατρική, ΕΚΠΑ
Κυρίτση Ελένη, Καθηγήτρια, Νοσηλευτική, ΠΑΔΑ
Τούτουζας Κωνσταντίνος, Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Σχέση της έκτοπης λιπώδους διήθησης του ήπατος και των μυών με την έκταση της περιφερικής αθηρωμάτωσης
Languages:
Greek
Translated title:
Correlation of ectopic fat infiltration of liver and muscles with atherosclerosis burden in peripheral arteries
Summary:
Introduction: Peripheral Artery Disease (PAD) is most commonly caused by atherosclerosis. PAD correlates strongly with risk of major cardiovascular events because it associates frequently with coronary and cerebral atherosclerosis. Adipose tissue (AT) is no longer viewed as a passive energy-storing depot and a growing body of evidence supports the concept that both quantitative and qualitative aspects of AT are critical in determining an individual’s cardiometabolic risk profile.
Purpose: The purpose of the present study is to specify the correlation of ectopic fat deposit in liver and muscles with the degree of atherosclerosis of peripheral arteries.
Material and Methods: The study population consists of 99 patients that undergone contrast and no-contrast Computed Tomography(CT) of the abdomen in Hippokration General Hospital of Athens in the period between 2015 and 2017. PAD was defined as stenosis>50% of the lumen of iliac arteries. Diagnosis of Abdominal Aorta Aneurysm (AAA) was defined as dilation >35mm. Analysis of CT images was performed with specific method for estimation of fat infiltration of liver and psoas muscles. Calcium burden of abdominal aorta and iliac arteries was measured for the assessment of peripheral arteries atherosclerosis burden. Statistical analysis was performed with chi-square or t-test, and with Spearman’s correlation of the parameters measured. Statistical significance was defined in the level <0,05.
Results: From the measurements performed in CT images, it has been shown that liver attenuation values (Hounsfield Units-HU) were negatively correlated with aorto-iliac calcium burden in the study population (r=-0,556, p<0,001). So, liver fat infliltration was more extended, when aorto-iliac calcium burden found to be higher. There was not significant correlation between psoas muscle attenuation values and aorto-iliac calcium burden (r=0,040, p=0,697). Besides, the difference of HU values between psoas muscles and spleen was negatively correlated with aortic-iliac calcium burden (r=-0,406 p<0,001). There was not found statistical significance between age of the patients and HU attenuation of liver (p=0,440), spleen (p=0,053) and muscles (p=0,120). Moreover, men in comparison with women had lower values of liver attenuation (p=0,026) and higher calcium burden in abdominal aorta and iliac arteries (p=0,004). It has been shown that aorto-iliac calcium burden was increased in the groups of patients with PAD and AAA compared to controls (p<0,001), whereas there was not statistical significant difference in liver and muscle ectopic fat between these three groups.
Conclusions: There is evidence that imaging markers of liver and muscle ectopic fat depots correlate with calcium burden in aorta and iliac arteries and thus with atherosclerosis burden in peripheral arteries. These imaging markers could possibly find application in the cardiometabolic risk stratification of the patients.
Main subject category:
Health Sciences
Keywords:
Peripheral artery disease, Adipose tissue, Liver fat infiltration, Muscle fat infiltration, Cardiometabolic risk
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
205
Number of pages:
97
File:
File access is restricted only to the intranet of UoA.

Angelopoulos Andreas Master.pdf
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