Unit:
Speciality Endovascular TechniquesLibrary of the School of Health Sciences
Supervisors info:
Γεώργιος Γερουλάκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Κακίσης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αχιλλέας Χατζηϊωάννου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος της ενδοαγγειακής αντιμετώπισης ανευρυσμάτων και διαχωρισμών θωρακοκοιλιακής αορτής σε ασθενείς με σύνδρομο Marfan
Translated title:
The role of endovascular treatment of thoracoabdominal aortic disease in patients with Marfan syndrome
Summary:
Objective: The review of Marfan syndrome and the evaluation of the role of endovascular treatment of thoracoabdominal aortic disease in patients with Marfan syndrome.
Methods: We performed a systematic literature review using PubMed and Google Scholar, searching for related scientific papers between 2008 and 2019. We included papers with series of patients treated for thoracoabdominal aneurysms or Type B dissection, with endografts.
Results: A total of 11 studies with 168 patients in total were identified for inclusion in this review. Even though the number of the patients participated in each study was small, reported outcomes were characterized by low perioperative morbidity and mortality and high technical success postoperatively. Nevertheless, high rates of endografts-related complications were observed in the follow up period. It is worth to mention as well that almost 50% of the patients had undergone previous open cardiac operation either of the ascending aorta or aortic arch, which classifies them as high operative risk patients.
Conclusions: Even though there is a lack of high quality evidence to support definite use of endovascular repair in Marfan patients, it can be very helpful in selected patients with Marfan syndrome and thoracoabdominal aortic disease. Long-term and randomized control trials along with further evolution of endovascular technology, which will make the endografts more ‘’friendly’’ towards the aorta, will be necessary in order to establish endovascular procedures as a ‘’Gold Standard’’ for this challenging patient population.
Keywords: Marfan syndrome, Endovascular treatment of aortic aneurysms in Marfan patient, Type B dissections, Connective tissue diseases and endovascular treatment.
Main subject category:
Health Sciences
Keywords:
Marfan syndrome, Endovascular treatment in Marfan patient, Type B dissections, Connective tissue diseases, Endovascular treatment
