Unit:
Specialty Molecular Biomedicine Mechanisms of Disease, Molecular and Cellular Therapies, and BioinnovationLibrary of the School of Health Sciences
Author:
Ferentinos Athanasios
Supervisors info:
Δρ. Δημήτριος Κοντογιάννης, Αναπληρωτής Καθηγητής, Τμήμα Βιολογίας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, "Alexander Fleming" B.S.R.C.
Δρ. Γεώργιος Κόλλιας, Καθηγητής, Τμήμα Ιατρικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών, "Alexander Fleming" B.S.R.C.
Δρ. Παναγιώτα Καφάσλα, Ερευνήτρια, "Alexander Fleming" B.S.R.C.
Original Title:
A study of the function of hnRNP A3 in the myeloid lineage and innate immunity
Translated title:
A study of the function of hnRNP A3 in the myeloid lineage and innate immunity
Summary:
The innate immune response against pathogens involves the activation of pro-inflammatory processes that need to be resolved once the threat is removed. The successful regulation of these responses relies on the production and posttranscriptional regulation of mRNAs encoding cytokines and RNA-binding proteins are major components of this posttranscriptional control. In this project, we studied the role of the RNA-binding protein hnRNP A3 under inflammatory conditions. Mice lacking hnRNP A3 in myeloid-lineage cells, which include many cells of the innate immune system, were also infected with bacterial pathogens. At the molecular level, activated macrophages from these mice displayed upregulation of both pro-inflammatory and anti-inflammatory markers. The results of this study indicate that hnRNP A3 is a downregulator of macrophage activation.
Main subject category:
Health Sciences
Keywords:
Macrophage, Inflammation, Post-transcriptional control, RBPs
