Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

2019-07-12

2019

Kyparissi Antigoni

Γεράσιμος Σιάσος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Ελένη Κυρίτση, Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, ΤΕΙ Αθηνών
Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Συσχέτιση του NT-proBNP με την έκταση της στεφανιαίας νόσου και τη σταδιοποίηση κατά Grace risk score σε ασθενείς με έμφραγμα του μυοκαρδίου χωρίς ανάσπαση του ST διαστήματος.

Greek

Correlation on NT-proBNP with the extent of coronary artery disease and the Grace risk score in patients with non ST elevation myocardial infraction.

Background/Objective: Non ST elevation myocardial infraction is a disease with a rising incidence. Due to this fact, the disambiguation of the optimal timing of revascularization is a matter of great importance. Currently, there is no established single objective biomarker, which could contribute to this decision. In this study we attempt to report a possible correlation between NT-proBNP, the extent-importance of coronary artery disease and the GRACE risk score. As a result, the aim of our study is the usage of NT-proBNP as a criterion of prompt revascularization.
Methods: Between 2017 and 2018, 30 consecutive patients presenting with Non ST myocardial infraction were included in this study. All of them underwent coronary angiography within a period of 48 hours since their admission. The mean age was 63.33 years. NT-proBNP and hs-TnT were included in the blood examination of all the patients. Consequently, medical record was examined, Grace Risk score was estimated and coronary angiography result was recorded. Patients were classified by their risk for death based on GRACE risk score in low, intermediate or high risk, and by the extent of coronary artery disease, in groups of one, two or three vessels disease.
Results: Statistical analysis brought out significant positive correlation between NT-proBNP and risk of death after acute myocardial infraction with non ST elevation, based on GRACE risk score (p<0.001). Howbeit, no significant correlation between NT-proBNP and the extent of coronary artery disease was ascertained. Statistical significant positive correlation was also found out between NT-proBNP and hs-TnT (p=0.004), while the latter could not be significantly correlated with the extent of coronary artery disease. Finally, the predictive value of Grace Risk score was confirmed in view of its statistically significant positive correlation with the extent of coronary artery disease based on the number of vessels disease (p=0.021).
Conclusion: In spite of the featured significant correlation between NT-proBNP and the risk of adverse outcome, after Non ST myocardial infraction, no significant correlation of NT-proBNP and the extent of coronary artery disease was mentioned, something that could empower the decision make for timely revascularization. More studies, with greater sample and consecutive measurements of NT-proBNP, are required to support this decision.

Health Sciences

Coronary artery disease, NT-proBNP, Grace risk score, NSTEMI

No

0

Yes

42

74

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https://pergamos.lib.uoa.gr/uoa/dl/object/2878678