Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Grigoriadis Sokratis
Supervisors info:
Μαρία Σιμοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μιχαήλ Κουτσιλιέρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Investigating the Value of Age 35 as a Cut-off Point regarding Decision Making in In Vitro Fertilization (IVF) Treatment: A Retrospective Data Analysis
Translated title:
Investigating the Value of Age 35 as a Cut-off Point regarding Decision Making in In Vitro Fertilization (IVF) Treatment A Retrospective Data Analysis
Summary:
Introduction: Clinicians are called to overcome age-related challenges in decision making during In Vitro Fertilization (IVF) treatment. The aim of this study was to assess the value of age 35 as a cut–off point regarding decision making in IVF in women of good prognosis.
Methods: Medical records between 2010 and 2017 of patients fulfilling the strict inclusion criteria were identified and analyzed. The study group consisted of women diagnosed with tubal factor infertility only. The sample size was divided in three categories at 34, 35 and 36 years of age. The single cycle concluded with one Embryo Transfer including two embryos performed on Day 5. Comparisons were performed regarding hormonal profile, response to stimulation, quality of transferred embryos, implantation and clinical pregnancy rates.
Results: A total of 353 women were eligible to participate. One-hundred and thirty four women were 34 years old, 108 were 35 years old and the remaining 111 were 36 years old. No statistically significant difference was observed between the three age groups regarding the hormonal profile, the number of oocytes collected and the quality of embryos transferred. Regarding the implantation rate, women aged 36 years old presented with a statistically significant decreased implantation rate in comparison to women aged 34 and 35 years old (RR: 0.62, 95% CI: 0.46-0.84, RR: 0.62, 95% CI: 0.46-0.82). Evaluating the clinical pregnancy rate, women aged 36 years old presented with a statistically significant decreased clinical pregnancy rate, in comparison to women aged 35 years old (RR: 0.74, 95% CI: 0.56-0.96).
Conclusions: Results indicate that implantation and clinical pregnancy rates are decreased for the patients aged 36 in comparison to the patients aged 35 when two embryos are transferred, indicating that the age 35 may serve as a valid cut-off point in the respective embryo transfer decision.
Main subject category:
Health Sciences
Keywords:
In Vitro Fertilization (IVF), Age 35, Age cut-off point, Infertility, Embryo transfer decision
Number of references:
183
