Unit:
Specialty Molecular Biomedicine Mechanisms of Disease, Molecular and Cellular Therapies, and BioinnovationLibrary of the School of Health Sciences
Author:
Angelopoulou Andriani
Supervisors info:
Αθανάσιος Κοτσίνας, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Βασίλης Γοργούλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σοφία Χαβάκη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
“Escape” from oncogene induced senescence
Translated title:
“Escape” from oncogene induced senescence
Summary:
The reversibility of senescence has been an issue highly disputable until recently, thus the factors driving this event remain still elusive. Using a human epithelial model, we recapitulate the whole spectrum of lung carcinogenesis, promoted by CDC6 overexpression, including the precancerous (senescent) state and the escape from senescence providing clear evidence about the increased proliferative capacity and aggressiveness acquired by the escaped clones. We also focus on the genetic and epigenetic determinants driving and/or contributing to the phenomenon of the oncogene induced escape from senescence. BHLHE40 was identified as a crucial gene, since an inversion in the region encoding this locus promoted the altered expression of numerous genes while it was found essential for the survival of the escapees. Apart from the genetic alterations, the aberrant expression of histone marks, such as H4K16ac, may facilitate the phenomenon by affecting the expression of genes related to senescence and the evasion from it. Further research is required to delineate the genetic and epigenetic contribution to the escape from oncogene induced senescence.
Main subject category:
Health Sciences
Keywords:
Senescence, CDC6, Oncogene, Escape, Genetic, Epigenetic
Number of references:
104
