Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2019-09-09

2019

Triantafyllou Maria

Ανδρέας Χ. Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Νικόλαος Γ. Καβαντζάς, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Περικλής Γ. Φούκας, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Μονοπάτια μεταγωγής σήματος του ανοσιακού συστήματος που ενέχονται στην παθογένεια του μελανώματος

Greek

Immune signaling pathways involved in melanoma pathogenesis

Melanoma is a rare but often fatal neoplastic disease. Melanoma cells specific features enable them to evolve and metastasise, even after years of lathrobiosis. These features became object of study after 1990, when the role of natural an artificial radiation became apparent. Malignant tumors' potential to deceive the immune system and escape immune surveillance triggered our prossecing of the immune cells and their stimulatory particles, a fact of the utmost significance in immunology-oncology.
The first part of this study refers to epidemiology and risk factors for the development of melanoma. Although a rare entity, its epiptosis rises. In an effort to understand this tendency, we cite the classical risk factors and also molecular biology elements, concerning molecular pathways and cell cycle interfering particles.
At the second part of this study, we describe the clinical characteristics, staging and prognosis of melanoma.
The third part of this study consists of an extensive and deep of the principles of cancer immunology. The major immunophysiologic mechanisms and specifically molecules PD-1, PD-L1 and CTLA4 are thoroughly explained. New particles and molecules-targets are also mentioned.
At the fourth and last parts, the collectible clinical data available are analyzed.

Health Sciences

Immune system, Cancer immunology, Immunotherapy, CTLA4, PD-1, PD-L1, PD-L2

No

0

Yes

131

63

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/2880537