Secondary cancer risk estimation for organs partially exposed to high doses of radiation in young and middle-aged patients treated with radiotherapy

Postgraduate Thesis uoadl:2881042 111 Read counter

Unit:
Κατεύθυνση Ιατρική Φυσική-Ακτινοφυσική
Library of the School of Health Sciences
Deposit date:
2019-09-23
Year:
2019
Author:
Koutrouli Maria
Supervisors info:
Μαζωνάκης Μιχαήλ, Επίκουρος Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Μαρής Θωμάς, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Περισυνάκης Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Original Title:
Εκτίμηση του κινδύνου εμφάνισης δευτερογενούς καρκίνου σε όργανα μερικώς εκτεθειμένα σε υψηλές δόσεις ακτινοβολίας λόγω ακτινοθεραπείας σε ασθενείς νεαρής και μέσης ηλικίας
Languages:
Greek
Translated title:
Secondary cancer risk estimation for organs partially exposed to high doses of radiation in young and middle-aged patients treated with radiotherapy
Summary:
Nowadays, radiotherapy is widely used in the treatment of many cases of solid tumors. The number of survivors of malignant diseases continuously rises and an increase in the incidence of cancer solid tumors has been observed in radiotherapy-treated patients relatively to the corresponding percentage of the general population not exposed to ionizing radiation, which is attributable to the development of secondary radiation-induced malignancies. This work focuses on the calculation of the risk for the development of secondary radiation – induced cancer – the excess absolute risk (EAR) and the lifetime attributable risk (LAR) – in 18 patients after radiotherapy, in organs that were partially in – field the primary irradiation beam, and therefore received inhomogeneous doses. This has been calculated using the concept of organ equivalent dose (OED), which is determined using three different non – linear dose – response curve models: the mechanistic model, which includes the impact of the fractionation of the dose and cell repopulation, the bell – shaped model, which assumes no cell repopulation and plateau model, which assumes full repopulation. These models were mainly defined through the study of the survivors of atomic bombs and patients with Hodgkin's lymphoma who received radiotherapy. The calculation of the risk of the development of secondary cancer after radiotherapy is personalized for each patient separately and then compared with the corresponding value for a population of the same age and gender that has not been irradiated or ill. The results are of great importance as they allow us to observe the potential long-term effects of radiation therapy on each patient and to attempt to minimize them, as well as being useful in monitoring the patients after radiotherapy.
Main subject category:
Health Sciences
Keywords:
Radiotherapy, Secondary, Cancer, Risk, OED
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
132
Number of pages:
123

Koutrouli Maria Master.pdf
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